Video Experimental Relacionado
Updated: Sep 10, 2025
06:47
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.5K
Deficiencia de vitamina D y fracturas periprotésicas
Emily M Pilc1, Amy Y Zhao2, Sanjay Kubsad3
1Eastern Virginia Medical School at Old Dominion University, 825 Fairfax Ave, Norfolk, VA, 23507, USA.
Journal of clinical orthopaedics and trauma
|August 21, 2025
Resumen
La deficiencia de vitamina D no aumentó el riesgo de fracturas periprotésicas postoperatorias después de la artroplastia total de cadera (THA) o de rodilla (TKA). Este estudio no encontró ninguna asociación entre los niveles de vitamina D y la incidencia de PPF o el riesgo de revisión.
Área de la Ciencia:
- Cirugía ortopédica
- Ciencias de la nutrición
- Epidemiología
Sus antecedentes:
- Las fracturas periprotésicas postoperatorias (PPF) son una complicación significativa después de la artroplastia total de cadera (THA) y rodilla (TKA).
- La deficiencia de vitamina D es un factor de riesgo potencial para la osteoporosis, que está relacionada con el PPF.
- Las suposiciones anteriores sugerían una alta prevalencia de deficiencia de vitamina D en pacientes con FPP.
Objetivo del estudio:
- Investigar la incidencia y el riesgo acumulados de FPP dentro de los 10 años posteriores a la THA o TKA en pacientes con deficiencia de vitamina D.
- Evaluar la asociación entre el estado de la vitamina D y la aparición de FPP.
- Determinar si la deficiencia de vitamina D afecta la necesidad de cirugía de revisión debido al PPF.
Principales métodos:
- Se realizó un análisis de cohorte retrospectivo utilizando la Red de Investigación TriNetX.
- Se identificaron pacientes sometidos a THA o TKA primario entre enero de 2010 y abril de 2021 con niveles de calcidiol sérico disponibles y al menos dos años de datos de seguimiento.
- Para comparar a los pacientes con y sin deficiencia de vitamina D en una proporción de 1: 1 se utilizó el emparejamiento de la puntuación de propensión.
Principales resultados:
- Un total de 15.226 pacientes fueron incluidos en el estudio.
- La incidencia acumulada de PPF fue menor en la cohorte con deficiencia de vitamina D en comparación con el grupo de control tanto para el THA (0,60% frente a 1,68%) como para el TKA (0,26% frente a 0,47%).
- No se encontró una asociación estadísticamente significativa entre la deficiencia de vitamina D y el riesgo de PPF después de THA (HR: 0, 69) o TKA (HR: 0, 80).
Conclusiones:
- La deficiencia de vitamina D no se asoció con una mayor incidencia o riesgo de fracturas periprotésicas postoperatorias después de la artroplastia total de cadera o rodilla.
- El estudio no encontró ninguna correlación entre la deficiencia de vitamina D y el riesgo de cirugía de revisión debido al PPF.
Videos de Conceptos Relacionados
01:25Role of Vitamins in Maintaining Bone Health
3.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.6K
01:29Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
01:23Role of Skin in Vitamin D Synthesis
5.6K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.6K
01:21Skeleton and Calcium Homeostasis
4.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.8K
01:31Essential Minerals for Bone Health
4.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.4K
01:22Connective Tissue Cell Types
3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K