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Síndrome de Lesch-Nyhan un enfoque dental: informe del caso
Priscilla Sena Souza Luz Campos1, Luís Cândido Pinto da Silva1, Paulo Franco Taitson1,2
1Department of Pediatric Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, MG, Brazil.
African health sciences
|August 21, 2025
Resumen
El síndrome de Lesch-Nyhan es un trastorno ligado al X causado por una falta de enzima HGPRT, que conduce a problemas neurológicos y a la automutilación. El cuidado dental y el alopurinol son tratamientos clave para controlar los síntomas y reducir el ácido úrico.
Área de la Ciencia:
- Genética y trastornos metabólicos
- Neurología
- Odontología
Sus antecedentes:
- El síndrome de Lesch-Nyhan (LNS) es un trastorno recesivo ligado al X poco frecuente.
- Es el resultado de una deficiencia en la enzima hipoxantina-guanina fosforibosiltransferasa (HGPRT).
- La deficiencia de HGPRT interrumpe el metabolismo de las purinas, lo que lleva a disfunción neurológica e hiperuricemia.
Palabras clave:
Deficiencia de HGPRTSíndrome de Lesch-NyhanEl amortiguador de labiosLa auto mutilaciónMás Videos Relacionados
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