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Efectos adversos y percepciones de los pacientes de los suplementos no regulados para la artritis: un estudio
Vi D Nguyen1, Elizabeth M Canales2, Kenneth Pettersen2
1Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus
|August 21, 2025
Resumen
Los pacientes que usan suplementos de artritis de venta libre sin saber de medicamentos ocultos como la dexametasona experimentaron un alivio significativo del dolor, pero también efectos adversos, incluida la insuficiencia suprarrenal. Muchos dejaron de usarlo después de la recomendación del médico.
Área de la Ciencia:
- Farmacología
- Salud pública
- Seguridad del paciente
Sus antecedentes:
- El uso de medicina complementaria y alternativa es común para el dolor crónico.
- Los suplementos de artritis de venta libre (OTC) a menudo se anuncian como naturales, pero pueden contener medicamentos recetados no revelados.
- Los ingredientes farmacéuticos ocultos presentan riesgos significativos para la salud sin supervisión clínica.
Objetivo del estudio:
- Investigar las experiencias, percepciones y motivaciones de los pacientes para el uso de suplementos de artritis de venta libre.
- Para entender por qué los pacientes usan estos suplementos a pesar de las advertencias de la FDA y el daño potencial.
- Evaluar el conocimiento de los pacientes sobre los ingredientes ocultos y los riesgos asociados.
Principales métodos:
- Los médicos identificaron pacientes que usaban suplementos de artritis de venta libre advertidos por la FDA.
- Las entrevistas telefónicas semiestructuradas evaluaron los datos informados por los pacientes.
- Se analizaron los datos clínicos y los niveles de cortisol para detectar eventos adversos.
Principales resultados:
- 12 pacientes informaron el uso de suplementos como Artri King que contienen medicamentos no revelados (dexametasona, diclofenaco, metocarbamol).
- Las motivaciones incluían recomendaciones, poco alivio de los tratamientos prescritos y la seguridad natural percibida.
- Los pacientes experimentaron alivio del dolor, pero informaron efectos secundarios, incluida la insuficiencia suprarrenal en 3/5 de los pacientes evaluados; ninguno sabía de los ingredientes ocultos.
Conclusiones:
- Los pacientes con dolor crónico continúan usando suplementos de venta libre debido a la seguridad percibida y la terapia convencional inadecuada, sin darse cuenta de los riesgos farmacéuticos ocultos.
- Los ingredientes no revelados en los suplementos conducen a eventos adversos graves, incluida la insuficiencia suprarrenal y problemas cardiovasculares.
- Los médicos deben evaluar el uso de suplementos, educar a los pacientes sobre los riesgos y promover estrategias más seguras de control del dolor.
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