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Fuentes de entrada sináptica a las neuronas en el núcleo Accumbens Shell que se proyectan hacia el pálido ventral

Shuanghong Li¹, Sa Li¹, Gilbert J Kirouac¹

¹Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

The Journal of comparative neurology

|August 21, 2025

Resumen

El subiculum ventral y el tálamo paraventricular anterior son entradas clave para las neuronas de la cáscara del núcleo accumbens que se proyectan hacia el pálido ventral, regulando la motivación y la liberación de dopamina.

Área de la Ciencia:

La neurociencia
Neurociencia del comportamiento
Neurociencia de los sistemas

Sus antecedentes:

El núcleo accumbens (NAcSh) es crucial para la motivación y la recompensa.
Influye en la liberación de dopamina y en la actividad de las neuronas dopaminérgicas del cerebro medio a través del sistema ventral estriatopalidal.

Objetivo del estudio:

Para identificar las fuentes de entrada sináptica en todo el cerebro a las neuronas NAcSh mediales que se proyectan hacia el pálido ventral ventromedial (VP).
Mapear la conectividad aferente de esta vía NAcSh-VP específica.

Principales métodos:

Rastreo de la rabia monosináptica en ratas para identificar las fuentes de entrada.
Trazado anterogrado para confirmar los objetivos de proyección de las vías de entrada identificadas.

Principales resultados:

El subiculum ventral (vSub) fue la mayor fuente de entrada a las neuronas NAcSh-VP.
El núcleo paraventricular anterior del tálamo (aPVT) fue otra fuente de entrada significativa.
Las entradas del vSub inervaron densamente el NAcSh, evitando otras regiones estriatales.
No se observaron diferencias significativas por sexo en las vías aferentes identificadas.

Conclusiones:

El vSub y el aPVT son las principales entradas corticales y tálamicas a las neuronas de proyección NAcSh-VP.
Estas entradas convergentes probablemente regulan el comportamiento y la liberación de dopamina en el NAcSh.

Palabras clave:

RRID:AB_1549585 Es el nombre de un grupo de personas que trabajan en el sector de la pesca.RRID:AB_2762833 Se refiere a las personas físicas.las entradas el núcleo accumbens La rabia el tálamo el rastreo Pálido ventral el subiculum ventral

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