Video Experimental Relacionado
Updated: Sep 10, 2025
09:57
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.8K
La intoxicación por guanfacina es un niño pequeño que presenta somnolencia prolongada y bradicardia sinusal: un
Sayaka Nagasawa1,2, Go Inokuchi2, Minami Daikai3
1Laboratory of Forensic Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Journal of analytical toxicology
|August 21, 2025
Resumen
Un niño experimentó somnolencia severa y bradicardia después de la ingestión accidental de guanfacina. Este caso pone de relieve la importancia de considerar la toxicidad de la guanfacina en pacientes pediátricos que presentan estos síntomas.
Área de la Ciencia:
- Farmacología
- Pediatría
- Toxicología
Sus antecedentes:
- La guanfacina es un medicamento para el trastorno por déficit de atención e hiperactividad (TDAH) que actúa sobre los receptores adrenérgicos alfa-2A.
- La actividad de los agonistas alfa-2 centrales puede provocar efectos adversos como somnolencia, bradicardia e hipotensión.
- La seguridad de los medicamentos pediátricos y el reconocimiento de la sobredosis son preocupaciones críticas de salud pública.
Objetivo del estudio:
- Para reportar el primer caso de intoxicación por guanfacina en un niño pequeño sin TDAH.
- Para documentar la concentración sérica de guanfacina en un caso de sobredosis pediátrica.
- Ayudar en el reconocimiento y diagnóstico de la toxicidad de la guanfacina en niños.
Principales métodos:
- Informe de caso de un niño de 6 años que presentaba somnolencia inexplicable y bradicardia.
- Exclusión de las causas comunes de los síntomas del paciente.
- Confirmación de la ingestión de guanfacina mediante análisis de suero por cromatografía líquida y espectrometría de masa cuádruple.
Principales resultados:
- El paciente presentaba somnolencia y bradicardia prolongadas.
- El análisis sérico confirmó una concentración de guanfacina de 6 ng/ml.
- El diagnóstico de intoxicación por guanfacina se estableció sobre la base de los síntomas y la concentración confirmada.
Conclusiones:
- La ingestión accidental de guanfacina puede causar toxicidad significativa en niños pequeños.
- Este caso subraya la necesidad de vigilancia en el diagnóstico de la toxicidad de la guanfacina en pacientes pediátricos.
- Las concentraciones séricas documentadas son valiosas para confirmar el diagnóstico y orientar el tratamiento.
Videos de Conceptos Relacionados
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
241
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
241
01:14CNS Depressants: Barbiturates and Benzodiazepines
467
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
467
01:14Decreased pulse rate
619
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
619
01:19Management of Insomnia
320
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
320
01:17Sleepwalking and Sleep Talking
313
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
313
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
296
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
296