Video Experimental Relacionado
Updated: Sep 10, 2025
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
16.6K
Manejo quirúrgico de la enfermedad inflamatoria intestinal de aparición muy temprana
Sarah J Ullrich1, Annie Le-Nguyen1, Monica Holder1
1Colorectal Center at Cincinnati Children's Hospital, Division of Pediatric General & Thoracic Surgery, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Journal of pediatric surgery
|August 21, 2025
Resumen
La intervención quirúrgica es necesaria en el 22% de los pacientes con enfermedad inflamatoria intestinal de aparición muy temprana (VEO-IBD). Factores como la raza negra, el diagnóstico temprano y la gravedad de la enfermedad influyen en la necesidad de cirugía en VEO-IBD.
Área de la Ciencia:
- Gastroenterología pediátrica
- Cirugía pediátrica
- Investigación de las enfermedades inflamatorias intestinales
Sus antecedentes:
- La incidencia de la enfermedad inflamatoria intestinal de inicio muy precoz (VEO-IBD) está aumentando en niños menores de seis años.
- VEO-IBD presenta características clínicas únicas, respuestas al tratamiento y resultados.
- El papel de la intervención quirúrgica en el VEO-IBD sigue siendo poco conocido.
Objetivo del estudio:
- Examinar las estrategias de manejo quirúrgico y los resultados en pacientes pediátricos diagnosticados con EVO-EII.
- Identificar los factores asociados con la necesidad de intervención quirúrgica en esta población.
Principales métodos:
- Una revisión retrospectiva de 121 pacientes con EVE-IBD diagnosticados entre enero de 2008 y mayo de 2024 en una sola institución.
- Los datos recogidos incluyeron datos demográficos, características clínicas y gravedad de la enfermedad.
- Se utilizaron estadísticas descriptivas para el análisis de los datos.
Principales resultados:
- La enfermedad de Crohn fue el fenotipo más común (61,2%), afectando a menudo el colon (62,8%).
- La intervención quirúrgica fue necesaria en el 21,5% de los pacientes, siendo la creación de ostomía y la resección intestinal procedimientos comunes.
- La raza negra, el diagnóstico antes de un año de edad, la disminución de la velocidad de la altura, la enfermedad perianal y la gravedad de la enfermedad se asociaron significativamente con la intervención quirúrgica.
Conclusiones:
- Este estudio, la revisión de un solo centro más grande, encontró una tasa de intervención quirúrgica del 22% en VEO-IBD.
- Los factores clave que influyen en la necesidad quirúrgica incluyen la raza negra, la edad en el momento del diagnóstico, la gravedad de la enfermedad, la disminución de la velocidad de la altura y la enfermedad perianal.
- Es esencial realizar más investigaciones para aclarar el papel y los resultados de la cirugía en el tratamiento de los casos heterogéneos de EVE-EII.
Videos de Conceptos Relacionados
01:21Inflammatory Bowel Disease V: Surgical Management
212
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
212
01:29Inflammatory Bowel Disease IV: Pharmacological Management
189
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
189
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
419
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
419
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
202
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
202
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
267
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
267
01:17Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540