Video Experimental Relacionado
Updated: Sep 10, 2025
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
27.2K
Enterocolitis mastocítica en un paciente con diarrea crónica
Serena Tseng1, Mohini Pathria2
1Pediatrics, UC Davis Health, Sacramento, California, USA.
BMJ case reports
|August 21, 2025
Resumen
La enterocolitis mastocítica, una afección rara, fue diagnosticada en un paciente con síndrome de intestino irritable predominante por diarrea crónica (SII-D). El tratamiento con antihistamínicos y prebióticos mejoró efectivamente los síntomas, ofreciendo una nueva vía terapéutica.
Área de la Ciencia:
- Gastroenterología
- Inmunología
- Histopatología
Sus antecedentes:
- La enterocolitis mastocítica es un trastorno gastrointestinal raro caracterizado por una mayor infiltración de mastocitos en la mucosa intestinal.
- El síndrome del intestino irritable con diarrea (IBS-D) es un trastorno funcional gastrointestinal común con síntomas superpuestos.
- La diferenciación entre el IBS-D y la enterocolitis mastocítica es crucial para el tratamiento adecuado del paciente.
Objetivo del estudio:
- Para reportar un caso de enterocolitis mastocítica en un paciente con una historia de larga data de sospecha de SII-D.
- Para resaltar el enfoque de diagnóstico que incluye colonoscopia y tinción inmunohistoquímica.
- Describir una estrategia de tratamiento eficaz que incluya antihistamínicos y prebióticos.
Principales métodos:
- Una paciente de unos 60 años con diarrea crónica y urgencia fecal se sometió a una colonoscopia.
- Se obtuvieron y analizaron biopsias gastrointestinales utilizando tinción inmunohistoquímica para CD117 para identificar la infiltración de mastocitos.
- La respuesta al tratamiento se evaluó en función de la mejora de los síntomas clínicos.
Principales resultados:
- El paciente fue diagnosticado con enterocolitis mastocítica basándose en los hallazgos de la biopsia, excluyendo la mastocitosis sistémica.
- El tratamiento inicial con cromolyn sodio fue ineficaz.
- Una combinación de antihistamínicos H1 y H2 y prebióticos condujo a una mejora significativa de los síntomas clínicos.
Conclusiones:
- La enterocolitis mastocítica debe considerarse en pacientes con SII-D refractario, siendo las biopsias y la coloración de mastocitos herramientas de diagnóstico clave.
- La suplementación prebiótica y probiótica, como se demostró en este caso, ofrece una opción terapéutica prometedora para la enterocolitis mastocítica.
- Este caso presenta un nuevo enfoque terapéutico para la enterocolitis mastocítica, no descrito previamente en la literatura médica.
Videos de Conceptos Relacionados
01:17Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540
01:30Inflammatory Bowel Disease II: Crohn's Disease
382
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
382
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
321
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
321
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
419
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
419
01:25Assessment of the Rectum and Anus
400
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
400
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
245
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
245