Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

38
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
38
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

32
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
32
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

34
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
34
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

36
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
36

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Anakinra for recurrent pericarditis: a retrospective evaluation of long-term effectiveness, initiation timing and tapering.

Rheumatology international·2026
Same author

Disease-related and psychosocial factors associated with difficult-to-manage and treatment-refractory axial spondyloarthritis: insights from the Greek AxSpA Registry.

Rheumatology international·2026
Same author

Computational intelligence using nailfold videocapillaroscopy for the prediction of carotid intima-media thickness in rheumatoid arthritis: a cohort-based study.

Rheumatology international·2026
Same author

Capillary Microvascular Dysfunction in Rheumatoid Arthritis: The Promising Role of Nailfold Videocapillaroscopy-A Narrative Review.

Life (Basel, Switzerland)·2026
Same author

Association of Triglyceride-Glucose Index with Angiographic Thrombus Burden in Patients with ST-Elevation Myocardial Infarction: A Prospective Observational Study.

Journal of clinical medicine·2026
Same author

Dynamic Trends of Secondary Tricuspid Regurgitation in Acute Heart Failure and Association With Outcomes.

The American journal of cardiology·2026

Video Experimental Relacionado

Updated: Sep 10, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.5K

Fisiopatología de la disfunción endotelial en la circulación de Fontan: desde el banco hasta el lado de la cama y

Amalia Baroutidou1, Artemios G Karagiannidis2, Theodoros Dimitroulas3

  • 1First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece.

Angiogenesis
|August 21, 2025
PubMed
Resumen

El procedimiento de Fontan, una cirugía para defectos cardíacos complejos, puede dañar la función de los vasos sanguíneos. Esta revisión explora cómo esta disfunción endotelial contribuye a los malos resultados de salud en los pacientes de Fontan.

Palabras clave:
Disfunción endotelialLas fuentesFisiopatologíaVentrículo únicoCorazón univentricularDisfunción vascular

Más Videos Relacionados

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.8K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.8K

Videos de Experimentos Relacionados

Last Updated: Sep 10, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.5K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.8K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.8K

Área de la Ciencia:

  • Cardiología
  • Biología vascular
  • Cirugía cardíaca pediátrica

Sus antecedentes:

  • El procedimiento de Fontan es una cirugía crítica para defectos cardíacos congénitos complejos.
  • Crea una hemodinámica única al separar los retornos venosos sistémicos y pulmonares.
  • Estas condiciones pueden perjudicar la función endotelial tanto en la circulación pulmonar como en la sistémica.

Objetivo del estudio:

  • Revisar la fisiopatía pulmonar y la vasculopatía sistémica después del procedimiento de Fontan.
  • Para enfatizar el vínculo entre la disfunción endotelial y los resultados clínicos.
  • Identificar las lagunas de conocimiento y las direcciones futuras de la investigación.

Principales métodos:

  • Revisión de la literatura de estudios sobre la fisiopatología de la circulación de Fontan.
  • Análisis de los mecanismos subyacentes a la disfunción endotelial.
  • Correlación de los cambios vasculares con los resultados clínicos.

Principales resultados:

  • La circulación de Fontan conduce a la disfunción endotelial en ambos lechos vasculares.
  • Los mecanismos fisiopatológicos interrelacionados contribuyen a la disfunción de los órganos finales.
  • La disfunción endotelial es un factor clave en la morbilidad de los pacientes de Fontan.

Conclusiones:

  • La comprensión de la vasculopatía de Fontan y la disfunción endotelial es crucial.
  • Se necesita más investigación para abordar las lagunas de conocimiento y mejorar los resultados de los pacientes.
  • La orientación de la disfunción endotelial puede mitigar la morbilidad en pacientes con Fontan.