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Encefalitis severa relacionada con el virus del herpes humano 7 diagnosticada con el uso de mNGS en pacientes
Xin Chen1, Huan Zhao1,2, Chunxue Jiang1
1Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Virology journal
|August 22, 2025
Resumen
La encefalitis grave en niños causada por el virus del herpes humano 7 (HHV-7) puede conducir a resultados deficientes. El tratamiento precoz con aciclovir y inmunosupresores puede mejorar el pronóstico de los niños inmunocompetentes con encefalitis por HHV-7.
Área de la Ciencia:
- Neurología pediátrica
- Enfermedades infecciosas
- Virología
Sus antecedentes:
- El virus del herpes humano 7 (HHV-7) puede causar encefalitis grave en niños inmunocompetentes.
- Comprender el perfil clínico y los resultados de esta condición es crucial para un tratamiento eficaz.
Objetivo del estudio:
- Describir las características clínicas, los resultados del examen y el pronóstico de los niños inmunocompetentes diagnosticados con encefalitis severa relacionada con el HHV-7.
Principales métodos:
- Se estudió una cohorte de doce niños inmunocompetentes con encefalitis severa por HHV-7.
- El ADN de HHV-7 se detectó en el líquido cefalorraquídeo utilizando secuenciación metagenómica de próxima generación (mNGS).
- Los pacientes fueron seguidos durante más de 6 meses.
Principales resultados:
- La cohorte fue predominantemente masculina (75%) con una edad media de 4,5 años, con fiebre y alteración de la conciencia.
- Los síntomas neurológicos requirieron la admisión en la Unidad de Cuidados Intensivos Pediátricos (UCIP) para todos los pacientes.
- Los hallazgos anormales de EEG (90,9%) y MRI (72,7%) fueron comunes; dos pacientes desarrollaron secuelas incluyendo epilepsia.
- Cuatro pacientes tuvieron mal pronóstico, con una muerte y otra discapacidad grave a los 6 meses.
Conclusiones:
- Los niños mayores e inmunocompetentes con encefalitis severa por HHV-7 enfrentan malos pronósticos y bajas tasas de supervivencia.
- El aciclovir empírico combinado con terapia inmunosupresora puede ofrecer mejores resultados.
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