Asociaciones entre Life's Crucial 9 y gravedad, mortalidad por cualquier causa y mortalidad cardiovascular en individuos con síndrome cardiovascular-renal-metabólico: el papel mediador de la aceleración fenotípica de la edad
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Resumen
Este resumen es generado por máquina.El cumplimiento de las pautas de estilo de vida de Life' s Crucial 9 (LC9) reduce significativamente la gravedad y el riesgo de mortalidad del síndrome cardiovascular-renal-metabólico (CKM). Las puntuaciones más altas de LC9 están relacionadas con mejores resultados, enfatizando el papel de LC9 en las estrategias de salud pública.
Área De La Ciencia
- Cardiología
- Nefrología
- Salud metabólica
Sus Antecedentes
- La Asociación Americana del Corazón (AHA) introdujo el síndrome cardiovascular-renal-metabólico (CKM).
- Life's Crucial 9 (LC9) es una guía actualizada de estilo de vida para la salud cardiovascular.
Objetivo Del Estudio
- Para explorar las asociaciones entre la LC9 y la gravedad del síndrome CKM.
- Investigar el vínculo entre la LC9 y la mortalidad por síndrome de CKM.
Principales Métodos
- Se utilizaron datos de la Encuesta Nacional de Salud y Nutrición (NHANES).
- Se emplearon análisis logísticos y de regresión de Cox, de spline cúbico restringido (RCS) y de mediación.
- Se incluyeron 7.647 pacientes en el análisis.
Principales Resultados
- Cada aumento del 10% en la puntuación de LC9 redujo el riesgo de síndrome CKM avanzado en un 37%.
- Las puntuaciones más altas de LC9 se correlacionaron con una menor mortalidad por todas las causas y cardiovascular.
- La aceleración fenotípica de la edad (PhenoAgeAccel) medió la asociación entre la LC9 y la gravedad de la CKM.
Conclusiones
- Las puntuaciones de LC9 muestran asociaciones negativas significativas con la gravedad y la mortalidad del síndrome de CKM.
- LC9 puede guiar las estrategias de salud pública para la prevención del síndrome de CKM y la reducción de la mortalidad.
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