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Marcadores inflamatorios y de coagulación sérica en la infección por GBS y resultados adversos del embarazo
Lin Li1, Xiaoying Wang2, Dan Li3
1Department of Obstetrics and Gynecology, Yingtan Maternal and Child Health Hospital, Yingtan, Jiangxi, China.
Biomarkers in medicine
|August 22, 2025
Resumen
La infección por estreptococos del grupo B (GBS) en mujeres embarazadas está relacionada con un mayor riesgo de eventos adversos durante el embarazo (EPA). La positividad de GBS se correlaciona con marcadores inflamatorios elevados y coagulación alterada, destacando su impacto en la salud materna y fetal.
Área de la Ciencia:
- Obstetricia y ginecología
- Enfermedades infecciosas
- Medicina materna y fetal
Sus antecedentes:
- El estreptococo del grupo B (GBS) es un patógeno importante en el embarazo.
- La infección por GBS puede provocar varios eventos adversos durante el embarazo.
- Comprender la interacción entre el GBS, la inflamación y la coagulación es crucial para manejar los resultados del embarazo.
Objetivo del estudio:
- Investigar la asociación entre la infección por GBS y las EPI en mujeres embarazadas.
- Para analizar los factores inflamatorios séricos (FI) y los parámetros de coagulación en mujeres GBS positivas con y sin APEs.
Principales métodos:
- Análisis retrospectivo de 2.200 mujeres embarazadas.
- Recopilación de datos sobre infección por SGB, serotipo, infecciones intestinales, parámetros de coagulación y EPI.
- Análisis comparativo y regresión logística para identificar los factores de riesgo.
Principales resultados:
- El 26,95% de las mujeres eran positivas para el SGB.
- Las mujeres con SGB tenían tasas significativamente más altas de parto prematuro, infección intrauterina, ruptura prematura de las membranas, ruptura de la placenta, hemorragia posparto y líquido amniótico manchado de meconio.
- El recuento elevado de glóbulos blancos, hs-CRP, TNF-α, IL-6, IL-1β, procalcitonina y fibrinógeno fueron factores de riesgo independientes para las EPA.
Conclusiones:
- La infección por GBS es un factor de riesgo significativo para eventos adversos en el embarazo.
- Las alteraciones en los marcadores inflamatorios y de coagulación están estrechamente asociadas con la infección por GBS durante el embarazo.
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