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Enfermedad de Cushing en la Autoridad Regional de Salud de Noruega Occidental
Ingrid Martinsen Amland1, Kristian Løvås2, Morten Lund-Johansen3
1Klinisk institutt 2, Universitetet i Bergen.
Resumen
La incidencia de la enfermedad de Cushing en el oeste de Noruega es mayor que la reportada anteriormente. El éxito del tratamiento para la enfermedad de Cushing depende de las características del tumor, lo que requiere estrategias terapéuticas personalizadas.
Área de la Ciencia:
- Endocrinología
- En el campo de la oncología
- Neurocirugía
Sus antecedentes:
- La enfermedad de Cushing es el resultado de un adenoma pituitario que secreta la hormona adrenocorticotrópica (ACTH), causando una producción excesiva de cortisol.
- Este estudio se centra en la incidencia, la presentación clínica y los resultados del tratamiento de la enfermedad de Cushing en el oeste de Noruega.
Objetivo del estudio:
- Para determinar la incidencia de la enfermedad de Cushing en el oeste de Noruega.
- Analizar las manifestaciones clínicas y los resultados del tratamiento.
- Para correlacionar los resultados con las características del tumor.
Principales métodos:
- Revisión retrospectiva de los expedientes médicos del Hospital Universitario de Haukeland (2010-2022).
- Inclusión de 42 pacientes diagnosticados con enfermedad de Cushing.
- Análisis de los resultados quirúrgicos (cirugía transfenoidal, radioterapia con cuchillo gamma) y adrenalectomía bilateral.
Principales resultados:
- Se identificaron 42 pacientes; la incidencia se estimó en 3,0 por millón al año.
- 33 pacientes presentaron trastornos metabólicos en el momento del diagnóstico; 25 lograron remisión después de la cirugía.
- Las tasas de remisión variaron según el tamaño del tumor: 2/7 macroadenomas, 12/21 microadenomas, 6/14 con resonancia magnética no concluyente.
Conclusiones:
- El oeste de Noruega muestra una mayor incidencia de la enfermedad de Cushing que otros estudios europeos.
- Los resultados del tratamiento están vinculados a las características del tumor, haciendo hincapié en los planes de tratamiento individualizados.
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