Video Experimental Relacionado

Updated: Sep 10, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Estrategias para sistemas de administración de fármacos a nanoescala para evadir la absorción hepática

Yanling Zhang¹, Dawei Chen¹, Ming Zhao¹

¹Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, PR China.

International journal of pharmaceutics

|August 22, 2025

Resumen

Los sistemas de administración de fármacos a nanoescala (NDDS) son prometedores, pero las nanopartículas (NP) a menudo son capturadas por el hígado. Las estrategias para evadir la absorción hepática son cruciales para la orientación extrahepática efectiva y el uso clínico.

Área de la Ciencia:

Ingeniería biomédica
Nanotecnología
Farmacología

Sus antecedentes:

Los sistemas de administración de fármacos a nanoescala (NDDS) ofrecen una mayor eficacia terapéutica y efectos secundarios reducidos.
La captura hepática de nanopartículas (NP) limita su aplicación clínica al dificultar la orientación extrahepática.

Objetivo del estudio:

Revisar los conceptos, las características y las aplicaciones de los NDDS.
Para elucidar los mecanismos de captación y depuración hepática de NP.
Hacer hincapié en las estrategias para eludir la absorción hepática para mejorar la administración de fármacos.

Principales métodos:

Revisión de la literatura existente sobre las interacciones NDDS y NP con el hígado.
Análisis de los mecanismos subyacentes a la absorción y el aclaramiento hepático de los NP.
Discusión de estrategias para modular las propiedades de NP y administración para reducir la captura hepática.

Principales resultados:

La captura hepática es una barrera significativa para la traducción clínica de NDDS.
Las propiedades fisicoquímicas moduladoras, las modificaciones superficiales y las vías de administración pueden reducir la absorción hepática de NP.
Existen varios métodos de evaluación para evaluar el comportamiento de NP in vivo.

Conclusiones:

Evitar la absorción hepática es crítico para maximizar el potencial terapéutico del NDDS.
El diseño estratégico de las PN es necesario para lograr una orientación extrahepática efectiva.
Se necesita más investigación y desarrollo para superar los desafíos de aclaramiento hepático en NDDS.

Palabras clave:

Métodos de evaluación Estrategias de evasión Absorción hepática Sistemas de administración de fármacos a nanoescala

Más Videos Relacionados

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Videos de Conceptos Relacionados

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Elimination: Non-Renal Routes

Drug Elimination: Non-Renal Routes

The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...

Factors Influencing Drug Absorption: Presystemic Elimination

Factors Influencing Drug Absorption: Presystemic Elimination

The pharmacokinetic journey of oral drugs begins with a crucial first pass through the hepatic portal system, called the first-pass effect. This first pass significantly impacts bioavailability — the proportion of a drug that enters systemic circulation and is available for therapeutic action. The primary route sees the drug absorbed by intestinal membranes and then shunted to the liver via the hepatic portal vein. Here, pre-systemic elimination occurs as drugs face metabolism or biliary...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...