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Microbioma oral entre pacientes con miocardiopatía hipertrófica no obstructiva y obstructiva
Qianyi Qin1, Yuming Zhu2, Liu Yang3
1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Chinese medical journal
|August 22, 2025
Resumen
El microbioma oral difiere entre los pacientes con cardiomiopatía hipertrófica no obstructiva (noHCM) y los pacientes con cardiomiopatía hipertrófica obstructiva (oHCM). Específicamente, los pacientes sin CMH muestran una mayor abundancia de Porphyromonas gingivalis, lo que podría influir en las distinciones clínicas.
Área de la Ciencia:
- Medicina cardiovascular
- Investigación del microbioma
- La genómica
Sus antecedentes:
- El papel del microbioma oral en la miocardiopatía hipertrófica (HCM) es en gran medida desconocido.
- No se han explorado las diferencias clínicas y microbianas entre la CMH no obstructiva (noCMH) y la CMH obstructiva (oCMH).
Objetivo del estudio:
- Investigar y comparar los perfiles del microbioma oral de los pacientes sin CMH y con CMH.
- Identificar los posibles biomarcadores microbianos asociados con los subtipos de CMH.
Principales métodos:
- Estudio transversal de 18 pacientes sin CMH y 26 con CMH.
- Análisis de muestras de placa clínica, periodontal y subgingival.
- Secuenciación metagenómica para composición microbiana y análisis funcional.
Principales resultados:
- No hay diferencias significativas en la diversidad o composición general del microbioma oral.
- Diez taxones mostraron diferencias significativas; Porphyromonas gingivalis fue más abundante en noHCM.
- El análisis funcional reveló distintas vías metabólicas entre los grupos no HCM y oHCM.
Conclusiones:
- Los niveles elevados de Porphyromonas gingivalis en noHCM pueden contribuir a las variaciones clínicas.
- Los cambios funcionales microbianos sugieren un metabolismo alterado del huésped en los subtipos de HCM.
- El análisis del microbioma oral ofrece información sobre la fisiopatología de la CMH.
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