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La señalización dinámica impulsada por la desmogleína en el pénfigo vulgar: una revisión sistemática de las vías
Siavash Rahimi1,2,3, William V J Hariton1,2, Fattaneh Khalaj4
1Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
NPJ Regenerative medicine
|August 22, 2025
Resumen
Las cadherinas desmosomales mantienen la integridad epitelial y la señal. Una revisión de la investigación de pemphigus vulgaris revela 128 moléculas de señalización involucradas en esta enfermedad autoinmune, que ofrecen ideas terapéuticas.
Área de la Ciencia:
- Biología celular
- Inmunología
- La biofísica
Sus antecedentes:
- La integridad del tejido epitelial depende de las uniones intercelulares, incluidos los desmosomas.
- Las cadherinas desmosomales son componentes estructurales clave y centros de señalización emergentes.
- Pemphigus vulgaris (PV) es un trastorno autoinmune que interrumpe la adhesión desmosomal.
Objetivo del estudio:
- Revisar sistemáticamente las vías de señalización patógena en el pénfigo vulgar (PV).
- Comprender el doble papel de las cadherinas desmosomales en la integridad estructural y la señalización celular.
- Para identificar las moléculas de señalización involucradas en la patogénesis PV.
Principales métodos:
- Revisión sistemática e imparcial de la literatura desde 1977 hasta mediados de 2024.
- Centrado en efectores de señalización patógenos validados funcionalmente en modelos de PV y pacientes.
- Análisis de 128 estudios y 128 moléculas de señalización.
Principales resultados:
- Identificó una red coherente de 128 moléculas de señalización en PV.
- Se destacan los eventos de señalización biomecánica, bioeléctrica y bioquímica interconectados.
- Confirmó el papel crítico de las cadherinas desmosomales en la patogénesis PV.
Conclusiones:
- Las cadherinas desmosomales son centrales tanto para la estructura epitelial como para las redes de señalización en PV.
- La red de señalización identificada proporciona una base para comprender la patogénesis PV.
- Este análisis puede orientar futuras estrategias terapéuticas para la PV y trastornos relacionados.
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