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Updated: Sep 10, 2025

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
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Published on: May 23, 2025

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Conocimientos moleculares de la metabolización de la acarbosa catalizada por la glucosidasa preferida por la acarbosa

Jiayong Huang1,2, Zhuanglin Shen2, Xiaoyun Xiao2

  • 1College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.

Nature communications
|August 22, 2025
PubMed
Resumen

Este estudio revela el mecanismo catalítico de la glucosidasa preferida por acarbosa (Apg), identificando a D448 como el nucleófilo activo. Este hallazgo ayuda en el diseño de fármacos hipoglucémicos mejorados como los análogos de la acarbosa.

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