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Obesidad infantil por edad y colelitiasis en adultos: asociación y bases transcriptómicas compartidas

Lihua Liu¹, Lu Zhang^1,2, Yiwen Liao¹

¹Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

International journal of obesity (2005)

|August 22, 2025

Resumen

La obesidad infantil, particularmente a edades específicas, tiene un vínculo causal con los cálculos biliares en adultos. La intervención temprana en la obesidad es clave, ya que el gen MLXIPL potencialmente ofrece objetivos terapéuticos para prevenir los cálculos biliares.

Área de la Ciencia:

Genética y Epidemiología
Salud pública
Trastornos del metabolismo

Sus antecedentes:

Se establece la asociación entre la obesidad y la colelitiasis (piedras de la vesícula).
La relación causal entre la obesidad infantil específica de la edad y los cálculos biliares en adultos sigue sin estar clara.
Los mecanismos biológicos subyacentes a esta asociación son poco conocidos, lo que dificulta la prevención dirigida.

Objetivo del estudio:

Investigar la relación causal entre el índice de masa corporal (IMC) infantil específico de la edad y la colelitiasis en adultos.
Explorar las señales genéticas y transcriptómicas compartidas que subyacen a esta asociación.
Identificar las vías biológicas potenciales para intervenciones específicas.

Principales métodos:

Se utilizaron estadísticas resumidas del estudio de asociación de todo el genoma (GWAS, por sus siglas en inglés) para el IMC infantil en 12 puntos temporales y la coletiasis en adultos.
Regresión de puntuación de desequilibrio de vinculación empleada (LDSC) para el análisis de correlación genética.
Se llevaron a cabo estudios de aleatorización mendeliana (MR) de dos muestras y multivariables, MR basado en resúmenes (SMR), estudios de asociación de todo el transcriptoma (TWAS) y colocalización bayesiana.

Principales resultados:

Se encontraron correlaciones genéticas significativas entre 11 IMC infantiles y colelitiasis en adultos específicos de la edad.
Los análisis de resonancia magnética confirmaron relaciones causales entre el IMC al nacer y varios momentos de la infancia (8 meses, 1,5, 7 y 8 años) y la colelitiasis adulta.
El gen MLXIPL fue identificado como la señal transcriptómica superpuesta más fuerte.

Conclusiones:

Proporciona evidencia de un vínculo causal entre la obesidad infantil en etapas clave del desarrollo y la formación de cálculos biliares en adultos.
Destaca la importancia de las intervenciones contra la obesidad infantil temprana.
Identifica la expresión génica de MLXIPL como una vía biológica potencial para estrategias terapéuticas contra ambas afecciones.

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