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Avances en la farmacoterapia para la enfermedad renal diabética: una revisión sistemática
Hongli Zhang1, Jiewen Chen2, Niansong Wang1
1Department of Nephrology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetes/metabolism research and reviews
|August 23, 2025
Resumen
El tratamiento de la enfermedad renal diabética (ERD) está evolucionando más allá de los métodos tradicionales. Los nuevos medicamentos y la medicina tradicional china (MTC) ofrecen estrategias prometedoras para mejorar los resultados renales y cardiovasculares de los pacientes diabéticos.
Área de la Ciencia:
- Nefrología
- Endocrinología
- Farmacología
Sus antecedentes:
- La enfermedad renal diabética (ERD) es una complicación importante de la diabetes, que conduce a la enfermedad renal en etapa terminal y a una mortalidad significativa.
- Los tratamientos actuales dirigidos al sistema renina-angiotensina dejan un riesgo residual de insuficiencia renal.
- Hay una necesidad de nuevos enfoques terapéuticos para manejar eficazmente la DKD.
Objetivo del estudio:
- Revisar las estrategias terapéuticas emergentes para la enfermedad renal diabética.
- Destacar el potencial de los nuevos agentes farmacológicos y la medicina tradicional china (MTC).
- Hacer hincapié en las ventajas de los enfoques multidireccionales en la gestión de la DGD.
Principales métodos:
- Revisión de la literatura actual sobre los tratamientos de la DKD.
- Análisis de nuevas clases de fármacos, incluidos los agonistas de los receptores GLP-1, los inhibidores de SGLT-2 y otros.
- Exploración del papel y el marco evolutivo de la MTC en DKD.
Principales resultados:
- Los fármacos novedosos como los inhibidores de SGLT-2 y los agonistas de los receptores GLP-1 muestran beneficios renales significativos.
- Los antagonistas no esteroideos de los receptores de mineralocorticoides y los antagonistas selectivos de los receptores de la endotelina también demuestran eficacia.
- La medicina tradicional china (MTC) presenta un enfoque holístico y multidireccional prometedor para el tratamiento de la enfermedad de la corteza.
Conclusiones:
- Las estrategias multidireccionales, que combinan nuevas farmacoterapias y la MTC, tienen un potencial transformador para la DMC.
- Estos enfoques pueden mitigar la progresión de la DKD, mejorar la salud cardiovascular y reducir las cargas sanitarias.
- La investigación futura debe centrarse en ensayos estandarizados, seguridad a largo plazo de la MTC y regímenes personalizados para obtener resultados óptimos para los pacientes.
Palabras clave:
DKD y DKDERA (en inglés)Prácticas de trabajo saludablesSGLT-2 (en inglés)TCM y sus derivadosnuevo MRAMás Videos Relacionados
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