Video Experimental Relacionado
Updated: Sep 10, 2025
10:34
A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
7.8K
Mapeo de la evolución de la investigación de los receptores de kainato durante cinco décadas: tendencias, puntos
Yunsheng Liu1,2, Rongde Zhong2, Yao-Xuan Li1
1Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Naunyn-Schmiedeberg's archives of pharmacology
|August 23, 2025
Resumen
Este análisis bibliométrico traza un mapa de cinco décadas de investigación sobre el receptor de kainato (KAR), revelando las principales tendencias y desafíos. Las direcciones futuras se centran en los medicamentos específicos de la subunidad y la traducción clínica para los trastornos neurológicos.
Área de la Ciencia:
- La neurociencia
- Farmacología
- Información bibliométrica
Sus antecedentes:
- Los receptores de kainato (KAR) son receptores de glutamato ionotrópicos cruciales involucrados en las funciones cerebrales como la plasticidad sináptica.
- La desregulación de los KAR está relacionada con afecciones neurológicas y psiquiátricas, especialmente la epilepsia.
Objetivo del estudio:
- Realizar un análisis bibliométrico exhaustivo de la investigación sobre el receptor de kainato (KAR) entre 1975 y 2024.
- Para mapear la evolución, identificar las tendencias, los puntos calientes y las fronteras emergentes en la investigación de KAR.
- Proporcionar una visión general de las contribuciones globales y el potencial de traducción para orientar futuros estudios.
Principales métodos:
- Análisis cienciométrico de 11.671 publicaciones de PubMed, Web of Science y Scopus utilizando CiteSpace, VOSviewer y Bibliometrix.
- Análisis de las tendencias de publicación, las contribuciones de los países/instituciones, el impacto de las revistas, la productividad de los autores y la evolución de las palabras clave.
- Agrupación temática y análisis de ráfagas de citas para identificar puntos calientes de investigación y cambios temporales.
Principales resultados:
- La investigación de KAR alcanzó su punto máximo a principios de la década de 2000, impulsada por estudios de clonación y distribución molecular, con una estabilización reciente.
- Los EE.UU. lideran en productividad e impacto; China muestra un crecimiento significativo después de 2015.
- Se identificaron las fases de investigación: caracterización molecular (1995-2005), estudios funcionales / de enfermedades (2005-2015) y tecnologías avanzadas (2015-2024).
Conclusiones:
- Sigue habiendo desafíos significativos en la traducción clínica de los moduladores KAR y en la comprensión de su papel en los trastornos psiquiátricos.
- La investigación futura debe dar prioridad al diseño de fármacos específico de las subunidades, a la innovación interdisciplinaria y a la colaboración mundial.
- Esta hoja de ruta bibliométrica destaca la evolución dinámica, los patrones de colaboración y las necesidades de traducción no satisfechas en la investigación de KAR.
Palabras clave:
Información bibliométricaAsociación de enfermedadesPerspectivas para el futuroReceptor de los kainatosAprendizaje y memoriaMás Videos Relacionados
Videos de Conceptos Relacionados
01:15G Protein-coupled Receptors
13.3K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
13.3K
01:24Non-gated Ion Channels
7.1K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.1K
01:22Opioid Receptors: Overview
1.8K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.8K
01:18Patch Clamp
5.7K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
5.7K
01:19Ligand-gated Ion Channels
12.7K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
12.7K
01:26Voltage-gated Ion Channels
8.6K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.6K