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Evaluación integrada de la farmacocinética y de las interacciones multidimensionales entre fármacos de los

Jun Ren¹, Jin Zhuo¹, Xuejing Sun¹

¹School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Chinese Medicine Guangdong Laboratory, Hengqin 519031, China.

Journal of pharmaceutical and biomedical analysis

|August 23, 2025

Resumen

En este estudio se investigaron las interacciones entre bufadienolides de Venenum Bufois. El tratamiento combinado alteró significativamente los parámetros farmacocinéticos, estableciendo una red de interacciones entre fármacos para un uso clínico racional.

Área de la Ciencia:

Farmacología
La medicina tradicional china
Química analítica

Sus antecedentes:

Los bufadienolidos de Venenum Bufois poseen una actividad farmacológica significativa.
No se han investigado las posibles interacciones entre bufadienolides en tratamiento combinado.

Objetivo del estudio:

Evaluar las interacciones farmacocinéticas entre tres bufadienolidos representativos (resibufogenina, bufalina y arenobufagina) bajo administración concomitante.
Establecer una red de interacción entre fármacos para los bufadienolidos.

Principales métodos:

Se ha desarrollado y validado un método UPLC-Qq-MS/MS para cuantificar los bufadienolidos.
Se analizaron datos farmacocinéticos utilizando modelos no compartimentales para tratamientos con un solo agente y tratamientos combinados.

Principales resultados:

Se observó una variabilidad farmacocinética significativa entre los bufadienolidos, lo que indica relaciones estructura- farmacocinética.
El tratamiento combinado condujo a alteraciones significativas en los parámetros farmacocinéticos debido a las interacciones mutuas del bufadienolido.

Conclusiones:

Estableció una red de interacción entre fármacos para los bufadienolidos.
Proporciona una base científica para la aplicación clínica racional de las formulaciones de Venenum Bufonis.
Facilita el desarrollo optimizado de terapias multicomponentes para enfermedades cardiovasculares.

Palabras clave:

Arenobufágina Bufadienolidos y sus derivados Bufalina y sus derivados Interacción entre fármacos Farmacocinética La resibufogenina

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