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La colonización intestinal por Veillonella promueve la infección por C. difficile en la enfermedad de Crohn
Ziyu Yang1, Jilin Wang2, Yifan Chen3
1Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China.
Cell host & microbe
|August 23, 2025
Resumen
Las bacterias orales, Veillonella, pueden empeorar la infección por Clostridioides difficile (CDI) en pacientes con enfermedad de Crohn. Esto ocurre alterando el metabolismo de los ácidos biliares, promoviendo la CDI y destacando nuevos objetivos terapéuticos.
Área de la Ciencia:
- Microbiología
- Gastroenterología
- Inmunología
Sus antecedentes:
- La enfermedad de Crohn (EC) es un trastorno inflamatorio intestinal crónico sin cura.
- Los pacientes con enfermedad de Crohn tienen un mayor riesgo de desarrollar una infección por Clostridioides difficile (CDI), empeorando su condición.
Objetivo del estudio:
- Investigar el papel de los comensales orales, específicamente Veillonella, en la promoción de la ICD en pacientes con enfermedad de Crohn.
- Esclarecer los mecanismos por los cuales Veillonella exacerba la inflamación intestinal y la ICD.
Principales métodos:
- Estudio clínico observacional prospectivo en pacientes con enfermedad de Crohn.
- Modelos animales de la inflamación intestinal.
- Análisis del metabolismo de los ácidos biliares y de la expresión del transportador (ASBT).
- Investigación de los efectos de los lipopolisacáridos de Veillonella parvula en los factores de transcripción (c-Jun, c-Fos).
Principales resultados:
- La colonización intestinal por Veillonella promueve la CDI en la enfermedad de Crohn.
- Veillonella parvula suprime el transportador de ácido biliar ASBT en ratones, reduciendo la reabsorción de ácido biliar.
- El aumento de la abundancia de Veillonella se correlaciona con el metabolismo alterado de los ácidos biliares en pacientes con enfermedad de Crohn.
- Los ácidos biliares elevados en la luz intestinal desencadenan la germinación de C. difficile.
- El lipopolisacárido de V. parvula induce c-Jun y c-Fos, regulando la expresión de ASBT.
Conclusiones:
- Los comensales orales como Veillonella pueden exacerbar enfermedades intestinales como la enfermedad de Crohn y la ICD.
- El mecanismo implica la supresión de ASBT, lo que lleva a un aumento de los ácidos biliares luminales que promueven la germinación de C. difficile.
- Los hallazgos ofrecen posibles estrategias terapéuticas para el tratamiento de la ICD en pacientes con enfermedad de Crohn.
Palabras clave:
Las medidas previstas en el presente ReglamentoEn el caso de Clostridioides difficileLa enfermedad de CrohnVeillonella parvula y sus variedadesPatogénesisGerminación de las esporasMás Videos Relacionados
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