Medicamentos compuestos personalizados para animales de compañía
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Ver abstracta en PubMed
Resumen
Este resumen es generado por máquina.Los veterinarios ahora pueden crear medicamentos personalizados impresos en 3D para mascotas usando mantequilla de maní. Este enfoque innovador garantiza una dosificación precisa y una administración aceptable para terapias veterinarias personalizadas.
Área De La Ciencia
- Medicina Veterinaria
- Ciencias farmacéuticas
- Tecnología de impresión 3D
Sus Antecedentes
- La creciente demanda de terapias veterinarias personalizadas requiere formas de dosificación adaptadas a los animales de compañía.
- La disponibilidad limitada de formulaciones ajustadas al peso, apetecibles y flexibles conduce al uso de medicamentos fuera de la etiqueta y a riesgos de composición manual.
- Las prácticas actuales plantean desafíos para lograr una dosificación precisa y evitar la toxicidad de los excipientes en medicina veterinaria.
Objetivo Del Estudio
- Desarrollar una plataforma de composición veterinaria bajo demanda utilizando la impresión 3D por extrusión semi-sólida (SSE).
- Utilizar la mantequilla de maní como excipiente preferido por la especie y compatible con los medicamentos para crear formulaciones veterinarias apetecibles.
- Producir dosis ajustables y unidades de medicación masticables para animales de compañía.
Principales Métodos
- Impresión 3D por extrusión semi-sólida (SSE) para el compuesto veterinario bajo demanda.
- Se ha formulado una matriz mejorada con almidón utilizando mantequilla de maní como excipiente principal.
- Incorporó prednisolona (PRE) en la matriz para crear unidades masticables con dosis ajustables.
Principales Resultados
- Unidades masticables impresas con éxito con características de extrusión robustas y una excelente linealidad de dosis (R2 > 0,99).
- Se consigue una liberación inmediata del fármaco y propiedades mecánicas adecuadas para la ingesta oral voluntaria.
- Estabilidad demostrada de las formulaciones impresas durante 14 días en condiciones de refrigeración.
Conclusiones
- Se introdujo una plataforma de impresión 3D escalable para mejorar la atención farmacológica veterinaria.
- Valida el uso de formulaciones a base de mantequilla de maní para la administración de medicamentos personalizados en animales de compañía.
- Destacó el potencial de esta tecnología para proporcionar una dosificación precisa, agradable y flexible para tratamientos veterinarios crónicos.
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