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Caracterización de las especies de lípidos plasmáticos en la disfunción metabólica asociada a la enfermedad hepática
Adeyinka Taiwo1,2, Himani Thakkar3, J Alan Maschek4
1Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa, 200 Hawkins Dr., E400 GH, Iowa City, 52242, IA, USA. adeyinka-taiwo@uiowa.edu.
Scientific reports
|August 23, 2025
Resumen
Las personas con diabetes tipo 1 y enfermedad hepática estatótica asociada a disfunción metabólica (MASLD) presentan un IMC y una resistencia a la insulina más altos. Los niveles elevados de ceramidas circulantes, diacilgliceroles y triacilgliceroles están relacionados con el desarrollo de MASLD en esta población.
Área de la Ciencia:
- Endocrinología
- Hepatología
- Síndrome metabólico
Sus antecedentes:
- La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD, por sus siglas en inglés) es la manifestación hepática del síndrome metabólico.
- La progresión de MASLD a esteatohepatitis (MASH) aumenta los riesgos de cirrosis, HCC y otras neoplasias malignas.
- Existen datos limitados sobre el MASLD y los perfiles lipídicos en la diabetes tipo 1 en comparación con la diabetes tipo 2.
Objetivo del estudio:
- Investigar la asociación entre las especies de lípidos clave y el MASLD en individuos con diabetes tipo 1.
- Identificar biomarcadores lipídicos específicos relacionados con la enfermedad en este grupo de pacientes.
Principales métodos:
- Estudio transversal de 30 participantes con diabetes tipo 1.
- Extracción de sangre en ayunas para la lipidomica dirigida.
- Evaluación por FibroScan de la presencia de esteatosis utilizando el parámetro de atenuación controlada (CAP).
- Casos definidos por la puntuación CAP ≥248, controles por la puntuación CAP <248.
Principales resultados:
- Los casos de MASLD tenían un IMC y dosis de insulina de 24 horas significativamente más altos que los controles.
- Los casos mostraron niveles circulantes elevados de ceramidas totales, diacilgliceroles y triacilgliceroles.
- Las dihidroceramidas, ceramidas, diacilgliceroles y triacilgliceroles circulantes se correlacionaron significativamente con la puntuación de esteatosis.
- No hay especies lipídicas correlacionadas con la puntuación de fibrosis.
Conclusiones:
- Los pacientes con diabetes tipo 1 con MASLD presentan un IMC más alto y una posible resistencia a la insulina.
- Los niveles elevados de dihidroceramidas, ceramidas, diacilgliceroles y triacilgliceroles circulantes están asociados con la patogénesis de la MASLD en la diabetes tipo 1.
- Estos lípidos pueden servir como biomarcadores potenciales para el MASLD en la diabetes tipo 1.
Palabras clave:
Índice de masa corporalEstudio transversalDiabetes mellitus y otras enfermedadesHígado grasoResistencia a la insulinaEstéatosisEl tipo 1Más Videos Relacionados
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