Video Experimental Relacionado

Updated: Sep 10, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Efecto de romosozumab en la densidad mineral ósea en pacientes con osteoporosis: una revisión sistemática y un

Hooman Yahyazadeh^1,2, Tahereh Farkhondeh³, Abolfazl Bagherifard⁴

¹Department of Orthopedic Surgery, Farhikhtegan Hospital, Faculty of Medicine, Tehran Medical Sciences Islamic Azad University, Tehran, Iran.

Current medicinal chemistry

|August 24, 2025

Resumen

Romosozumab aumenta significativamente la densidad mineral ósea (DMO) en pacientes con osteoporosis, mejorando la DMO de la columna lumbar, la cadera total y el cuello femoral. Los marcadores de rotación ósea pueden verificar estos efectos positivos.

Área de la Ciencia:

Endocrinología
La ortopedia
Farmacología

Sus antecedentes:

Romosozumab es un fármaco osteoanabólico eficaz para la osteoporosis, desarrollado basado en el conocimiento de la vía de señalización Wnt.
El tratamiento de la osteoporosis requiere medicamentos eficaces para mejorar la densidad mineral ósea (DMO).

Objetivo del estudio:

Revisar el impacto de romosozumab en la DMO en pacientes con osteoporosis.
Para analizar los cambios en los marcadores del metabolismo óseo junto con las mejoras en la DMO.

Principales métodos:

Una revisión sistemática de ensayos controlados aleatorios (ECA) publicados hasta enero de 2024 en PubMed, Web of Science y Scopus.
Metaanálisis de 24 ECA utilizando los índices g de Hedges agrupados para calcular las diferencias medias estandarizadas en los marcadores de DMO y metabolismo óseo.

Principales resultados:

El tratamiento con romosozumab provocó un aumento de la DMO de la columna lumbar en pacientes con osteoporosis.
Se observaron mejoras significativas en la DMO total de cadera y cuello femoral en la mayoría de los estudios incluidos.

Conclusiones:

Romosozumab aumenta efectivamente la DMO en la columna lumbar, la cadera total y el cuello femoral en pacientes con osteoporosis.
Los marcadores de rotación ósea como PINP, TRACP-5b y CTX pueden corroborar la eficacia de romosozumab.

Palabras clave:

DMAE en el cuerpo Compuesto orgánico Es el TRACP-5b.

Más Videos Relacionados

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Videos de Conceptos Relacionados

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...