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Updated: Sep 10, 2025
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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Calpain-1, no Calpain-2, tiene relación con las variables de la vía de señalización HMGB1 / TLR4 / NF-KB en la
Firdevs Uluc1, Sule Aydin Turkoglu2, Bihter Gokce Celik1
1Department of Interdisciplinary Neuroscience, Institute of Health Sciences, Bolu Abant İzzet Baysal University, Bolu, Turkey.
Neurological research
|August 24, 2025
Resumen
Los niveles de Calpain-1 y Calpain-2 están elevados en pacientes con esclerosis múltiple (EM) y trastorno del espectro óptico de la neuromielitis (NMOSD), lo que sugiere un papel en la neuroinflamación a través de la vía HMGB1.
Área de la Ciencia:
- Neuroinmunología
- La neuroinflamación
- Enfermedades desmielinizantes
Sus antecedentes:
- La comprensión de las vías de señalización es crítica para las enfermedades desmielinizantes como la EM y NMOSD.
- La vía HMGB1 / TLR4 / NF-κB está implicada en la neuroinflamación.
Objetivo del estudio:
- Investigar la relación entre Calpain-1 (CAPN1) y Calpain-2 (CAPN2) y la vía HMGB1/TLR4/NF-κB.
- Para comparar estos marcadores en pacientes con esclerosis múltiple (EMP) y trastorno del espectro óptico de la neuromielitis (EMP).
Principales métodos:
- ELISA se utilizó para medir los niveles de CAPN1, CAPN2, HMGB1, TLR4 soluble (sTLR4) y NF-κB.
- El estudio incluyó 36 pwMS, 9 pwNMOSD y 28 controles (pwPTC).
Principales resultados:
- pwMS exhibió niveles significativamente más altos de CAPN1 y CAPN2 en comparación con pwNMOSD y controles.
- No se observaron diferencias significativas en los niveles de HMGB1, sTLR4 o NF-κB entre los grupos.
- Se encontraron correlaciones positivas entre CAPN1 y CAPN2 en pwMS, y entre CAPN1 y HMGB1 en pwMS.
Conclusiones:
- CAPN1 puede contribuir a la neuroinflamación en la EM a través de la señalización HMGB1.
- Se requieren más investigaciones con cohortes más grandes y estudios longitudinales.
- Investigar la inhibición de CAPN1 podría ofrecer conocimientos terapéuticos para la EM.
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