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La transcriptómica espacial desentraña la red interactiva del cáncer gástrico impulsado por la aflatoxina B1:
Yong-Le Li1, Cong Liu2, Meng Tang1
1School of Clinical Medicine, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China.
Ecotoxicology and environmental safety
|August 24, 2025
Resumen
La aflatoxina B1 (AFB1) impulsa el cáncer gástrico al dirigirse a genes clave como el CCNE1/2. Este estudio traza el mapa de AFB1
Área de la Ciencia:
- Toxicología ambiental
- Oncología molecular
- Investigación del cáncer
Sus antecedentes:
- Los contaminantes ambientales, especialmente las micotoxinas, representan un riesgo significativo para la salud.
- La aflatoxina B1 (AFB1) es un potente carcinógeno, pero su papel en la carcinogénesis gástrica no se comprende completamente.
Objetivo del estudio:
- Para aclarar los mecanismos moleculares de la carcinogénesis gástrica inducida por AFB1.
- Para identificar los genes reguladores centrales dirigidos por AFB1.
- Trazar un mapa de la red reguladora multiómica de AFB1 en el cáncer gástrico.
Principales métodos:
- Simulaciones de acoplamiento molecular para evaluar la afinidad de unión de AFB1 a los genes objetivo.
- Secuenciación de ARN unicelular (scRNA-seq) de tejidos de cáncer gástrico humano.
- Transcriptómica espacial (10X Visium) para analizar la expresión génica en el microambiente del tumor.
Principales resultados:
- AFB1 tiene como objetivo cinco genes reguladores centrales, que regulan al alza CCNE1 y CCNE2.
- MAPK3 mostró la mayor afinidad de unión a AFB1.
- Se observó la expresión específica del tipo celular de los genes diana en las células inmunes, especialmente en las células T.
Conclusiones:
- AFB1 promueve sinérgicamente la progresión del cáncer gástrico al dirigirse a genes específicos.
- Se construyó un mapa de regulación molecular de múltiples capas de la carcinogénesis gástrica inducida por AFB1.
- Este estudio establece un nuevo paradigma para la integración multiómica en la toxicología ambiental.
Palabras clave:
Contaminantes ambientales; micotoxinas; aflatoxina B1; cáncer gástrico; multiómica; aleatorización mendeliana; microambiente inmuneMás Videos Relacionados
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