Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

277
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
277
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

446
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
446
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

512
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
512
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

640
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
640
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

274
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
274

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

[Comparison of efficacy and safety between two different methods of nephroureterectomy in two centers].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2019
Same author

Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure.

Journal of postgraduate medicine·2019
Same author

[Morphometric analysis program combined with magnetoencephalogram in the localization of epileptogenic foci in MRI-negative pharmacoresistant focal epilepsy patients].

Zhonghua yi xue za zhi·2019
Same author

Ultra-slow light in one-dimensional Cantor photonic crystals.

Optics letters·2018
Same author

Time-resolved inline digital holography for the study of noncollinear degenerate phase modulation.

Optics letters·2018
Same author

[Clinical features and gene analysis of TBC1D24 gene mutation related early-onset focal myoclonic epilepsy].

Zhonghua yi xue za zhi·2018

Video Experimental Relacionado

Updated: Sep 10, 2025

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
06:55

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

Published on: November 21, 2024

881

[Neuromodulación basada en la red cerebral para la epilepsia: estado actual y perspectivas]

Z S Li1, Y C Lin2, Y P Wang1

  • 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Zhonghua yi xue za zhi
|August 24, 2025
PubMed
Resumen

La epilepsia es un trastorno de la red cerebral. Esta revisión explora las estrategias de neuromodulación para la epilepsia resistente a los medicamentos, abogando por la remodelación de la red sobre el control de las convulsiones para el tratamiento personalizado.

Más Videos Relacionados

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.2K

Videos de Experimentos Relacionados

Last Updated: Sep 10, 2025

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
06:55

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

Published on: November 21, 2024

881
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.2K

Área de la Ciencia:

  • Neurología
  • La neurociencia
  • Ingeniería biomédica

Sus antecedentes:

  • La epilepsia afecta a millones, con ~ 30% experimentando epilepsia resistente a los medicamentos (ERD).
  • La epilepsia se entiende cada vez más como un trastorno de las redes cerebrales.
  • Los avances en neuroimagen y teoría de redes permiten nuevos enfoques de neuromodulación.

Objetivo del estudio:

  • Revisar sistemáticamente los avances recientes en la modulación de la red de epilepsia.
  • Centrarse en la identificación precisa y la modulación de los centros de la red epiléptica.
  • Explorar estrategias para la epilepsia generalizada y los desafíos actuales.

Principales métodos:

  • Revisión sistemática de la literatura científica vigente.
  • Análisis de las técnicas de neuroimagen y la teoría de la red cerebral.
  • Evaluación crítica de las estrategias de neuromodulación existentes y emergentes.

Principales resultados:

  • Progreso en la identificación y modulación de los centros de la red epiléptica en la epilepsia focal.
  • Desarrollo de estrategias de modulación de la red cerebral para la epilepsia generalizada.
  • Identificación de los principales desafíos y direcciones futuras en el campo.

Conclusiones:

  • La neuromodulación ofrece vías prometedoras para el tratamiento de la epilepsia resistente a los medicamentos.
  • Se aboga por un cambio de paradigma hacia la "reconstrucción funcional de la red".
  • Este enfoque facilita estrategias de neuromodulación más precisas y personalizadas para pacientes con epilepsia.