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Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies

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Mapeo de la nutrición y la investigación de la tuberculosis: Perspectivas desde una perspectiva bibliométrica

Chenqi Li^1,2, Biao Gao³, Hongmei Xiao⁴

¹Department of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, China.

Clinical and experimental pharmacology & physiology

|August 25, 2025

Resumen

Este estudio traza el panorama de la investigación sobre la nutrición y la tuberculosis (TB). Los resultados muestran un cambio hacia las redes integradas, con la vitamina D en el centro, y destacan la microbiota intestinal y los ácidos grasos como fronteras de investigación emergentes para la gestión de la tuberculosis.

Área de la Ciencia:

Inmunología nutricional
Investigación de enfermedades infecciosas
Información bibliométrica

Sus antecedentes:

La desnutrición y la tuberculosis (TB) presentan un ciclo perjudicial que afecta los resultados de los pacientes.
La investigación existente sobre las intervenciones nutricionales para la TB carece de una clara caracterización estructural y fronteriza.

Objetivo del estudio:

Analizar sistemáticamente la estructura, la evolución y las fronteras de la investigación en el campo de la nutrición y la tuberculosis.
Utilizar métodos bibliométricos para una cartografía completa del conocimiento de esta área de investigación.

Principales métodos:

Análisis bibliométrico de 4502 registros de la colección Web of Science Core (2007-presente).
Software CiteSpace utilizado para la ocurrencia conjunta, la visualización de la línea de tiempo y la detección de ráfagas de palabras clave, citas y autores.
Métricas de centralidad de la red aplicadas para identificar los nodos clave de investigación.

Principales resultados:

La vitamina D es un nodo central de investigación, que vincula la ciencia básica con las aplicaciones clínicas de la tuberculosis.
La investigación evolucionó desde los mecanismos moleculares hasta la validación clínica y la integración de la biología de sistemas.
Las fronteras emergentes incluyen la microbiota intestinal y los ácidos grasos; la comorbilidad diabetes-TB destaca las interacciones metabólicas-inmunes.

Conclusiones:

La investigación en nutrición y tuberculosis está avanzando hacia redes integradas de nutrición, microbioma, metabolismo e inmunidad.
La investigación futura debe dar prioridad a la nutrición de precisión, la multiomía y la traducción clínica, especialmente para las poblaciones de alto riesgo.
La gran cantidad de citas de los informes de la OMS pone de relieve la necesidad de traducir las políticas.

Palabras clave:

Análisis de la red de co-ocurrencia de clúster La nutrición la tuberculosis Vitamina D y sus derivados

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