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Los bacteriófagos contra la Salmonella enterica: desafíos y oportunidades
Nalleyt Segundo-Arizmendi1,2, Alejandra Paola Flores-Coria2, Janeth Gómez-Garcia2
1Laboratory 9: Microbiology and Parasitology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.
Frontiers in bioengineering and biotechnology
|August 25, 2025
Resumen
La terapia con fagos (PT) es prometedora para combatir la Salmonella resistente a los antibióticos. Los desafíos en la producción y la regulación actualmente limitan su aplicación farmacéutica global.
Área de la Ciencia:
- Microbiología
- Enfermedades infecciosas
- Biotecnología
Sus antecedentes:
- Salmonella spp. y sus derivados. es un importante patógeno transmitido por los alimentos que causa infecciones en humanos.
- Las cepas de Salmonella resistentes a los antibióticos representan una amenaza significativa para la salud pública.
- La terapia de fagos (PT) utiliza virus específicos para atacar las bacterias.
Objetivo del estudio:
- Revisar el estado actual de la terapia de fagos para la Salmonella.
- Analizar las oportunidades y los desafíos para el PT como producto farmacéutico.
Principales métodos:
- Revisión de la literatura sobre el estado de la técnica de la terapia de fagos.
- Análisis de las aplicaciones actuales y las limitaciones de PT.
Principales resultados:
- La terapia con fagos es eficaz contra la Salmonella y está comercializada por 41 empresas.
- La producción compleja y los obstáculos regulatorios obstaculizan el uso farmacéutico global de PT.
Conclusiones:
- La terapia con fagos es una estrategia prometedora contra la Salmonella entérica resistente a los antibióticos.
- Abordar los desafíos de producción y regulación es crucial para la adopción generalizada de PT.
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