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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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Video Experimental Relacionado

Updated: Sep 10, 2025

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Comprender la interacción entre la melatonina y las bifidobacterias

Sonia Mirjam Rizzo1, Giulia Longhi1, Chiara Tarracchini1

  • 1Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma 43124, Italy.

Microbiome research reports
|August 25, 2025
PubMed
Resumen

Leche de mujer

Palabras clave:
CST (en inglés)Melatonina y sus derivadosBifidobacteriasmicrobios intestinaleslas hormonas

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Área de la Ciencia:

  • Microbiología
  • Fisiología humana
  • Biología molecular

Sus antecedentes:

  • La microbiota intestinal, una comunidad microbiana compleja, se forma al nacer y está influenciada por factores como la lactancia materna.
  • La leche materna contiene melatonina, una hormona crucial para regular los ciclos de sueño y vigilia y establecer los ritmos circadianos en los recién nacidos.
  • Comprender la interacción entre los componentes de la leche y los microbios intestinales del bebé es vital para la salud del bebé.

Objetivo del estudio:

  • Investigar las interacciones moleculares entre la melatonina humana y la microbiota intestinal infantil rica en bifidobacterias.
  • Explorar cómo la melatonina influye en la función y la expresión génica de las bacterias intestinales infantiles.

Principales métodos:

  • Se utilizaron ensayos in vitro para evaluar la comunicación molecular.
  • Empleó enfoques genómicos funcionales para analizar las respuestas microbianas.

Principales resultados:

  • La melatonina indujo impactos funcionales distintos en las especies bifidobacterianas tanto a nivel transcripcional como fenotípico.
  • Efectos observados dependientes de la especie de la melatonina en la adhesión microbiana a las células intestinales.

Conclusiones:

  • Bifidobacterium bifidum exhibió la interacción molecular más significativa con la melatonina entre los taxones bifidobacterianos analizados.
  • La melatonina juega un papel clave en la modulación de la composición y la función de la microbiota intestinal infantil, particularmente a través de interacciones con bifidobacterias específicas.