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Leucoplasia peluda oral: una participación rara en un paciente con policitemia vera
Yuri de Lima Medeiros1, Dandara Menezes de Araujo Oliveira1, Agnaldo Rocha Prata Júnior1
1Department of Stomatology, A.C.Camargo Cancer Center, São Paulo, SP, Brazil.
Resumen
La leucoplasia peluda oral (LPO), un signo de inmunosupresión, fue diagnosticada en un paciente con policitemia vera. La detección temprana de OHL durante la progresión de la enfermedad puede mejorar los resultados de los pacientes.
Área de la Ciencia:
- Medicina Oral
- Hematología
- En el campo de la oncología
Sus antecedentes:
- La leucoplasia peluda oral (LPO) está típicamente asociada con neoplasias hematológicas e indica inmunosupresión.
- Los informes de OHL en policitemia vera (PV) son raros, lo que hace que este caso sea significativo.
Objetivo del estudio:
- Para informar el primer caso conocido de leucoplasia oral peluda en un paciente diagnosticado con policitemia vera.
- Resaltar el papel potencial de la OHL como un indicador temprano de la progresión de la enfermedad y la inmunosupresión.
Principales métodos:
- Examen clínico de un paciente varón de 54 años con policitemia vera con lesiones bilaterales en la lengua.
- Análisis histopatológicos y de hibridación in situ para confirmar el diagnóstico de OHL.
- Seguimiento de la progresión de la enfermedad, incluido el desarrollo de esplenomegalia y mielofibrosis, y respuesta al tratamiento.
Principales resultados:
- El paciente fue diagnosticado con OHL basado en hallazgos clínicos y patológicos.
- El paciente progresó a mielofibrosis post-policitemia vera y fue tratado con ruxolitinib y trasplante de células madre hematopoyéticas alogénicas.
- La remisión completa de la lesión de leucoplasia peluda oral se logró después del trasplante.
Conclusiones:
- La leucoplasia peluda oral puede ocurrir en pacientes con policitemia vera, particularmente durante la progresión de la enfermedad a la mielofibrosis.
- La presencia de OHL puede servir como marcador para la inmunosupresión subyacente y el avance de la enfermedad.
- La identificación temprana de la OHL en este contexto podría conducir a mejores resultados para los pacientes.
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