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HTSNPedia: una perspectiva molecular y una base de datos de estimación de riesgos para los genes asociados a la

Jeyanthi Sankar¹, Agnal Arumugam², A Antony Prakash²

¹Pharmacogenomics and CADD Lab, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India.

Biochemical genetics

|August 25, 2025

Resumen

La hipertensión, un problema de salud mundial, involucra factores genéticos y epigenéticos complejos. Una nueva base de datos, HTSNPedia, integra datos sobre SNPs asociados a la hipertensión, vías y factores de riesgo para ayudar al descubrimiento de fármacos.

Área de la Ciencia:

Genética y Epigenética
Investigación de las enfermedades cardiovasculares
La bioinformática

Sus antecedentes:

La hipertensión afecta a más de mil millones de adultos en todo el mundo, impulsada por factores genéticos y epigenéticos.
Las vías de señalización clave como RAAS, KKS y el sistema de endotelinas están implicadas en el desarrollo de la hipertensión.
La comprensión de estas interacciones complejas es crucial para el manejo eficaz de la hipertensión.

Objetivo del estudio:

Desarrollar una base de conocimiento integral para la investigación de la hipertensión.
Integrar información sobre los SNPs, las vías biológicas, los factores de riesgo y la farmacogenómica.
Facilitar la identificación de nuevos medicamentos candidatos para el tratamiento de la hipertensión.

Principales métodos:

Desarrolló la base de datos HTSNPedia utilizando HTML y Java.
Datos integrados sobre los polimorfismos de nucleótido único (SNP) asociados con la hipertensión.
Se incluye información sobre las vías biológicas relevantes, la evaluación de riesgos, los mecanismos moleculares y la farmacogenómica.

Principales resultados:

Creó una base de datos de acceso abierto, HTSNPedia.
La base de datos facilita la integración de diversas informaciones relacionadas con la hipertensión.
Se espera que mejore la eficiencia de la identificación de nuevos objetivos farmacológicos.

Conclusiones:

HTSNPedia mejora la integración de los datos relacionados con la hipertensión.
Una comprensión más profunda de las bases moleculares de la hipertensión puede mejorar la salud humana.
La base de datos apoya la investigación de nuevas terapias para la hipertensión y la medicina personalizada.

Palabras clave:

Calculadora de la presión arterial Estimador del riesgo de HTN Hipertensión Base de datos de los SNPs En el caso de las PNMS

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