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Acceso al espacio subdural de la médula espinal de los roedores para la administración del tratamiento
Salvador Lopez1, Chien Kow2, Manju Ganesh3
1School of Pharmacy, University of Auckland; salvador.lopez@auckland.ac.nz.
Journal of visualized experiments : JoVE
|August 25, 2025
Resumen
Un nuevo método permite el acceso directo al espacio subdural de la médula espinal para mejorar el tratamiento de los trastornos neurológicos. Esta técnica proporciona terapias y dispositivos de manera segura sin causar déficits funcionales en los roedores.
Área de la Ciencia:
- La neurociencia
- Ingeniería biomédica
- La Medicina Regenerativa
Sus antecedentes:
- El tratamiento de las enfermedades y lesiones de la médula espinal es difícil debido al limitado acceso directo a la médula espinal.
- Las terapias epidurales actuales para la lesión de la médula espinal (LME) carecen de interacción directa con el cordón, lo que puede limitar la eficacia del tratamiento.
Objetivo del estudio:
- Desarrollar y validar un nuevo protocolo para acceder al espacio subdural de la médula espinal en un modelo de roedor.
- Para permitir la administración directa y localizada de agentes terapéuticos y dispositivos bioelectrónicos para trastornos de la médula espinal.
Principales métodos:
- Se estableció un protocolo quirúrgico para acceder al espacio subdural en roedores.
- Se implantó un dispositivo bioelectrónico para el registro/estimulación de la médula espinal por vía subdural.
- Un hidrogel cargado de neurotrofina-3 fue insertado en el espacio subdural.
Principales resultados:
- Se realizó con éxito la implantación subdural del dispositivo bioelectrónico y la inserción de hidrogel.
- Los animales no mostraron déficits funcionales en las extremidades traseras o delanteras después del procedimiento.
- No se observaron disfunciones hasta 12 semanas después de los procedimientos.
Conclusiones:
- El protocolo propuesto proporciona un acceso seguro y efectivo al espacio subdural de la médula espinal.
- Este método permite la administración directa y localizada del tratamiento, mejorando el potencial terapéutico para los trastornos neurológicos.
- La técnica es adaptable para diversas aplicaciones en el tratamiento de la médula espinal y la investigación.
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