Video Experimental Relacionado
Updated: Sep 10, 2025
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
844
Diferencias en las estimaciones de la carga de la enfermedad renal crónica: de diferentes fuentes, definiciones y
Yao Ma1, Xiang Wang2, Weihong Zhao1
1Division of Nephrology, Department of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.
PloS one
|August 25, 2025
Resumen
La estimación de la carga de la enfermedad renal crónica varía según la fuente de datos y el método de cálculo. Los umbrales ajustados por edad y la ecuación EKFC ofrecen una mayor precisión para la prevalencia de ERC en entornos de investigación y clínicos.
Área de la Ciencia:
- Nefrología
- Epidemiología
- Salud pública
Sus antecedentes:
- El estudio Global Burden of Disease (GBD) proporciona datos epidemiológicos sobre la enfermedad renal crónica (ERC).
- Existen discrepancias entre las estimaciones de GBD y otras fuentes, lo que requiere una investigación adicional.
- Las herramientas estándar y computacionales para la tasa de filtración glomerular (GFR) requieren una consideración cuidadosa.
Objetivo del estudio:
- Evaluar la carga de la ERC utilizando diversas fuentes de datos, definiciones y ecuaciones.
- Para comparar las estimaciones de prevalencia de ERC del estudio GBD y la Encuesta Nacional de Examen de Salud y Nutrición (NHANES).
- Evaluar el impacto de las diferentes ecuaciones de GFR y los umbrales ajustados por edad en la prevalencia de ERC.
Principales métodos:
- Análisis de la prevalencia de ERC en adultos estadounidenses (1999-2018) utilizando datos de GBD 2021 y NHANES.
- Cálculo de la prevalencia media y del cambio porcentual anual estimado (EAPC) por sexo.
- Comparación de varias definiciones y ecuaciones, incluida una revisión global de la literatura.
Principales resultados:
- Las estimaciones anuales promedio de prevalencia de ERC de GBD y NHANES fueron similares, pero las tendencias a largo plazo divergieron, especialmente en grupos específicos de sexo.
- La eliminación de los coeficientes raciales alteró las estimaciones de prevalencia de ERC para los individuos negros y blancos.
- La ecuación EKFC dio como resultado la mayor prevalencia de ERC; los umbrales adaptados a la edad redujeron la baja prevalencia de eGFR en ~50%.
Conclusiones:
- Existen diferencias significativas en la prevalencia estimada de ERC entre varias fuentes y metodologías.
- Los umbrales ajustados por edad y la ecuación EKFC flexible muestran potencial para mejorar la evaluación de la ERC.
- Estos hallazgos tienen implicaciones para la investigación epidemiológica y la práctica clínica en el manejo de la ERC.
Videos de Conceptos Relacionados
01:28Chronic Kidney Disease III: Interprofessional Care
78
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
78
01:25Chronic Kidney Disease I: Introduction
67
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
67
01:17Factors Affecting Renal Clearance: Renal Impairment
157
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
157
01:22Acute Kidney Injury I: Introduction
72
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
72
01:24Chronic Kidney Disease II: Clinical Manifestations
87
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
87
01:11Renal Failure: Dose Adjustments
153
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
153