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Updated: Sep 10, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Inhibidores nucleosídicos de la transcriptasa inversa como oportunidad terapéutica para contrarrestar las

Fabiola Olivieri¹, Angelica Giuliani², Massimiliano Bonafè³

¹Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Advanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy.

Ageing research reviews

|August 25, 2025

Resumen

Los inhibidores nucleosídicos de la transcriptasa inversa (INRT) muestran efectos antiinflamatorios mediante la inhibición de los inflamasomas. Estos medicamentos pueden reducir las enfermedades relacionadas con la edad al dirigirse a los retroelementos endógenos activos, lo que sugiere el potencial de reutilización de medicamentos.

Área de la Ciencia:

Gerontología
Inmunología
Farmacología

Sus antecedentes:

Los inhibidores nucleosídicos de la transcriptasa inversa (INTR) se usan para el VIH y la hepatitis B.
Los NRTIs exhiben propiedades antiinflamatorias al inhibir la activación del inflamatorio.
Los estudios epidemiológicos relacionan el uso de INTR con la reducción de la incidencia de enfermedades relacionadas con la edad como el Alzheimer y la diabetes tipo 2.

Objetivo del estudio:

Revisar las pruebas mecanicistas y clínicas que relacionan a los IRNT con la reducción de la inflamación.
Investigar los efectos de las NRTIs sobre los retroelementos endógenos (LINE, SINE, HERV).
Explorar el potencial de las INTR para la reutilización de fármacos en enfermedades relacionadas con la edad.

Principales métodos:

Revisión de los estudios mecanicistas y epidemiológicos existentes.
Análisis de los mecanismos NRTI dirigidos a la transcriptasa inversa y las especies de ácido nucleico.
Evaluación de la toxicidad mitocondrial asociada a los NRTIs y de la seguridad de los compuestos más nuevos.

Principales resultados:

Los NRTIs inhiben la activación del inflamatorio y reducen la inflamación estéril.
Los retroelementos endógenos activos (LINE, SINE, HERV) contribuyen a la inflamación.
Los NRTIs pueden mitigar la inflamación al bloquear los híbridos de ARN:ADN dependientes de la transcriptasa inversa.

Conclusiones:

Los NRTIs son prometedores para el tratamiento de las enfermedades relacionadas con la edad mediante la lucha contra la inflamación.
La reutilización de fármacos de las INTR es una estrategia convincente para las afecciones relacionadas con la edad.
Se justifica el desarrollo de nuevos INTR con efectos secundarios reducidos.

Palabras clave:

La enfermedad de Alzheimer Enciende el fuego Las NRTIs Inhibidores nucleósidos de la transcriptasa inversa Transcripción inversa Diabetes tipo 2

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