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Informe de caso de virus del herpes humano tipo 4 combinado con Brucella abortus meningitis

Jingjing Yang^1,2, Feixiang Zhang², Xiaolong Guo^2,3

¹Affiliated Baotou Clinical College of Inner Mongolia Medical University, Baotou, Inner Mongolia, 014000, China.

BMC infectious diseases

|August 26, 2025

Resumen

Este estudio de caso detalla un caso raro de herpesvirus humano tipo 4 (HHV-4) y meningitis por Brucella abortus. El tratamiento efectivo incluyó antibióticos y glucocorticoides, mejorando los resultados de los pacientes.

Área de la Ciencia:

Neurología
Enfermedades infecciosas
Microbiología

Sus antecedentes:

El herpesvirus humano tipo 4 (HHV-4) y la meningitis por Brucella abortus es una coinfección rara.
Esta condición presenta desafíos diagnósticos y terapéuticos para los médicos.

Objetivo del estudio:

Analizar las características clínicas, el diagnóstico y el tratamiento de la meningitis por HHV-4 y Brucella abortus.
Mejorar el conocimiento clínico y las estrategias de tratamiento para esta rara encefalitis.

Principales métodos:

Un estudio de caso de una paciente de mediana edad diagnosticada con co-infección.
Análisis de los datos clínicos, incluidos los síntomas y las pruebas de diagnóstico (macrogenómica, pruebas de aglutinación).

Principales resultados:

El paciente presentaba mareos, entumecimiento de las extremidades y debilidad.
Las pruebas fueron positivas para HHV-4 y Brucella abortus.
Mejora significativa de los síntomas con doxiciclina, rifampicina, cotrimoxazol y acetato de prednisona.

Conclusiones:

La meningitis por HHV-4 y Brucella abortus es una rara encefalitis infecciosa con un mal pronóstico y una alta tasa de recurrencia.
Se recomienda un tratamiento por etapas con antibióticos y glucocorticoides.
Esta estrategia ayuda a controlar los síntomas agudos y a reducir el riesgo de recurrencia.

Palabras clave:

Meningitis por brucellas El HHV-4 Secuenciación del macrogenoma de segunda generación (mNGS)

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