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Asociaciones del índice aterogénico del plasma y otros parámetros lipídicos no tradicionales con el riesgo de

Yuhan Qin¹, Yong Qiao², Gaoliang Yan²

¹Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China. qinyuhanzd@163.com.

European journal of medical research

|August 26, 2025

Resumen

El metabolismo lipídico aberrante está relacionado con los aneurismas de las arterias coronarias (CAA). El índice aterogénico de plasma (AIP) mostró el potencial predictivo más alto para la AAC, lo que indica su importancia en la evaluación del riesgo.

Área de la Ciencia:

Medicina cardiovascular
Lipidología
Investigación metabólica

Sus antecedentes:

El metabolismo lipídico aberrante está implicado en el desarrollo de aneurismas de la arteria coronaria (CAA).
Existe una investigación limitada sobre la asociación entre los parámetros lipídicos tradicionales y no tradicionales y la AAC en pacientes sometidos a angiografía coronaria.

Objetivo del estudio:

Investigar y comparar los efectos de varios parámetros lipídicos en el desarrollo de la AAC.
Identificar los principales indicadores de lípidos para predecir la incidencia de la AAC.

Principales métodos:

Se incluyeron 160 pacientes con AAC y 160 controles.
Parámetros lipídicos tradicionales y no tradicionales calculados.
Se emplearon análisis logísticos multivariados, spline cúbico restringido (RCS) y curvas ROC para la evaluación de la asociación y la predicción.

Principales resultados:

Los pacientes con AAC presentaron niveles más altos de triglicéridos (TG), índice aterogénico plasmático (AIP), índice combinado de lipoproteínas (LCI), AC, CRI- I y CRI- II.
Se observaron niveles más bajos de colesterol de lipoproteínas de alta densidad (HDL-C) y colesterol remanente (RC) en el grupo de AAC.
El AIP demostró el mayor poder predictivo para la AAC (AUC = 0,712).

Conclusiones:

Pacientes con AAC con parámetros lipídicos tradicionales alterados.
El índice aterogénico de plasma (AIP) surgió como un predictor significativo de la AAC.
Los parámetros lipídicos no tradicionales, en particular el AIP, ofrecen información valiosa sobre el riesgo de AAC.

Palabras clave:

Índice aterogénico del plasma Aneurisma de las arterias coronarias Parámetro lipídico no tradicional Triglicéridos

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