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La artritis reumatoide y el riesgo de cáncer colorrectal: un estudio de cohorte nacional
Keun Hye Jeon1, Jinhyung Jung2, Mi Hee Cho3
1Department of Family Medicine, CHA Gumi Medical Center, CHA University School of Medicine, Gumi, Republic of Korea.
Rheumatology (Oxford, England)
|August 26, 2025
Resumen
La artritis reumatoide (AR) está relacionada con un menor riesgo de cáncer colorrectal (CRC), especialmente en pacientes y mujeres con AR seronegativa. Esta asociación inversa fue más significativa para el cáncer rectal.
Área de la Ciencia:
- Reumatología
- Gastroenterología
- En el campo de la oncología
Sus antecedentes:
- La artritis reumatoide (AR) es una enfermedad inflamatoria crónica con asociaciones complejas con varios tipos de cáncer.
- Los estudios previos sobre la AR y el riesgo de cáncer colorrectal (CRC) tenían limitaciones, incluida la falta de datos específicos del subsitio y la consideración del estado serológico de la AR.
Objetivo del estudio:
- Investigar la asociación entre la artritis reumatoide (AR) y el riesgo de cáncer colorrectal específico del sitio.
- Para analizar esta asociación basada en el estado serológico de la AR y los factores demográficos.
Principales métodos:
- Utilizó la base de datos del Sistema Nacional de Seguro de Salud de Corea para un estudio de cohorte.
- Se incluyeron 40.909 pacientes con AR y 204.945 controles emparejados, seguidos durante una mediana de 5,3 años.
- Utilizó la regresión multivariable de Cox para estimar los ratios de riesgo (RR) para la incidencia de CCR.
Principales resultados:
- Los pacientes con AR mostraron una disminución del riesgo general de CCR (RH, 0,89).
- Se observó una asociación inversa significativa en la AR seronegativa (RH, 0, 79) y en el cáncer de recto (RH, 0, 63).
- El riesgo reducido de CCR en pacientes con AR fue más pronunciado en mujeres (RH, 0,80).
Conclusiones:
- Existe una notable asociación inversa entre la artritis reumatoide y el riesgo de cáncer colorrectal.
- Este efecto protector es particularmente evidente en los casos de AR seronegativa, cáncer de recto y mujeres.
- Los hallazgos ponen de relieve la importancia de considerar los subtipos de AR y los subsitios de cáncer en la evaluación del riesgo.
Palabras clave:
Cáncer colorrectalLa artritis reumatoideArtritis reumatoide seronegativaArtritis reumatoide seropositiva En el caso de la artritis reumatoide seropositivaMás Videos Relacionados
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