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Sistemas de administración de fármacos implantables e inyectables para el tratamiento del dolor
Yujie Lu1, Ilyas Essadki-Aittaji2, Jiaqi Gao1
1School of Pharmacy, Queen's University Belfast, Belfast, UK.
Expert opinion on drug delivery
|August 26, 2025
Resumen
El control eficaz del dolor es crucial, ya que el dolor crónico afecta a millones de personas en todo el mundo. Los sistemas de administración de medicamentos implantables ofrecen un alivio del dolor localizado y sostenido, reduciendo los efectos secundarios y la dependencia de opiáceos para mejores resultados para los pacientes.
Área de la Ciencia:
- Tratamiento del dolor
- Sistemas de administración de medicamentos
- Cuidados postoperatorios
Sus antecedentes:
- El dolor es un problema de salud global que afecta la calidad de vida y causa discapacidad.
- El 20-30% de la población mundial experimenta dolor crónico no relacionado con el cáncer.
- Más del 80% de los pacientes quirúrgicos experimentan dolor postoperatorio agudo, con un control inadecuado en muchos casos.
Objetivo del estudio:
- Revisar las estrategias actuales de tratamiento del dolor, centrándose en las terapias postoperatorias no orales.
- Para resaltar los sistemas inyectables e implantables de administración de medicamentos para el control del dolor.
- Hacer hincapié en los dispositivos implantables sólidos para la administración sostenida y localizada de medicamentos.
Principales métodos:
- Revisión de la literatura sobre las estrategias actuales de tratamiento del dolor.
- Centrarse en las terapias no orales para el dolor postoperatorio.
- Análisis de los sistemas inyectables e implantables de administración de fármacos, en particular de los dispositivos sólidos implantables.
Principales resultados:
- Los sistemas de liberación controlada implantables están surgiendo como alternativas efectivas a los tratamientos farmacológicos tradicionales.
- Estos sistemas proporcionan un alivio del dolor localizado, reduciendo la exposición sistémica al medicamento.
- Los beneficios incluyen efectos secundarios minimizados, uso reducido de opiáceos y menor riesgo de adicción.
Conclusiones:
- Los sistemas de administración de fármacos implantables ofrecen una solución prometedora para mejorar el manejo del dolor postoperatorio.
- La administración localizada del fármaco aumenta la eficacia y la seguridad del paciente.
- Estos sistemas avanzados abordan los desafíos en los métodos actuales de control del dolor.
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