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El papel del complemento en la patogénesis de la COVID larga
Rafael Bayarri-Olmos1,2,3, William Bain4,5, Akiko Iwasaki1,2,3
1Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
JCI insight
|August 26, 2025
Resumen
El COVID largo, una condición crónica después de la infección por SARS-CoV-2, implica diversos síntomas que afectan la vida diaria. La evidencia emergente sugiere que la desregulación del sistema del complemento puede conducir su patología.
Área de la Ciencia:
- Inmunología
- Enfermedades infecciosas
- Patología
Sus antecedentes:
- El COVID largo es una condición crónica y multisistémica después de la infección por SARS-CoV-2.
- Afecta la función diaria y el trabajo de al menos el 10% de las personas infectadas.
- Los mecanismos subyacentes de Long COVID siguen siendo poco conocidos.
Objetivo del estudio:
- Revisar la evidencia que vincula la desregulación del sistema del complemento con el COVID largo.
- Explorar el papel del sistema del complemento en la patogénesis del COVID largo.
Principales métodos:
- Revisión de la literatura de estudios recientes.
- Examen de la investigación sobre la respuesta inmune y la patología de la enfermedad.
Principales resultados:
- Estudios recientes sugieren que la desregulación del sistema del complemento está implicada en el COVID largo.
- Esta desregulación puede estar relacionada con la coagulación, la inflamación y la lesión vascular.
Conclusiones:
- La desregulación del sistema de complemento es un posible contribuyente al COVID largo.
- Se necesita más investigación para aclarar completamente su papel en la patología de la enfermedad.
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