Video Experimental Relacionado

Updated: Sep 10, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

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Estructura cryo-EM de un receptor β1-adrenérgico humano de longitud completa sin células en complejo con Gs

Felipe Merino1, Zoe Köck2, Utz Ermel3

  • 1Cube Biotech GmbH, Monheim, Germany.

Structure (London, England : 1993)
|August 26, 2025
PubMed
Resumen

El tercer bucle intracelular del receptor β1-adrenérgico (ICL3) es crucial para la señalización de la proteína G. Su estructura revela interacciones mejoradas, mejorando la activación de la proteína G y la señalización cAMP.

Palabras clave:
Lízatos de E. coliComplejo GPCRGs heterotrimeroReceptores beta-adrenérgicosexpresión de proteínas libres de célulasinserción de la membrana cotranslacionalCrio-EMel bucle intracelular 3Los nanodiscosregulación de la señalización

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