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Linfoma de malta que afecta a la cavidad oral: un estudio clínico, patológico y genético de la translocación del gen
Juan Manuel Arteaga Legarrea1, Mauro Lima Dos Santos1, Nathalia Gomes Rodrigues1
1Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Oral surgery, oral medicine, oral pathology and oral radiology
|August 26, 2025
Resumen
Este estudio examinó el linfoma oral MALT, encontrando que es una neoplasia indolente con un buen pronóstico. No se detectaron translocaciones del gen MALT1 en los casos evaluados.
Área de la Ciencia:
- En el campo de la oncología
- Patología
- Inmunohistoquímica
Sus antecedentes:
- El linfoma del tejido linfoide asociado a la mucosa (MALT) puede afectar a la cavidad oral.
- Comprender sus características clínico patológicas, inmunohistoquímicas y moleculares es crucial para el diagnóstico y el pronóstico.
Objetivo del estudio:
- Investigar las características clínicas patológicas, inmunohistoquímicas y moleculares del linfoma MALT en la cavidad oral.
Principales métodos:
- Revisión retrospectiva de los casos de linfoma oral MALT de una institución brasileña.
- Confirmación del diagnóstico mediante tinción H&E y inmunohistoquímica.
- Análisis molecular para la translocación del gen MALT1 utilizando FISH.
Principales resultados:
- Se analizaron once casos, con tumores localizados en el paladar duro, el paladar blando y el suelo de la boca.
- La inmunohistoquímica reveló positividad CD20, linfocitos T reactivos CD3, BCL2 positivo y un índice Ki67 bajo.
- No se detectaron translocaciones del gen MALT1 en los cinco casos analizados molecularmente.
Conclusiones:
- El linfoma oral MALT es una neoplasia indolente con un pronóstico favorable.
- No se observó translocación de MALT1 en esta serie de casos de linfoma oral MALT.
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