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Updated: Sep 10, 2025

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

Sección multiómica de la regulación metabólica y transcripcional subyacente a la maduración de los frutos en Panax

Xingbo Bian¹, Yingxuan Qiu¹, Xue Zhao²

¹School of Pharmaceutical Sciences, Jilin Medical University, Jilin, 132013, Jilin, China.

BMC plant biology

|August 26, 2025

Resumen

Este estudio descifra la regulación molecular de la acumulación de compuestos bioactivos en el desarrollo de la fruta de Panax ginseng. Revela los genes clave y las vías metabólicas que controlan la producción de ginsenosidos, flavonoides y antocianinas durante la maduración.

Área de la Ciencia:

Biología vegetal
Biología molecular
La bioquímica

Sus antecedentes:

El Panax ginseng es una planta medicinal con frutos ricos en nutrientes que contienen valiosos compuestos bioactivos.
Comprender la regulación de estos compuestos durante el desarrollo de la fruta es crucial pero en gran medida desconocido.

Objetivo del estudio:

Investigar los mecanismos moleculares que rigen la acumulación de compuestos bioactivos en la fruta del ginseng Panax.
Crear un atlas completo del metabolismo y la expresión génica durante el desarrollo de la fruta.

Principales métodos:

Análisis metabolómicos y transcriptómicos integrados en cuatro etapas de desarrollo.
Perfiles de metabolitos y construcción de atlas de expresión génica.
Análisis ponderado de la red de coexpresión génica.

Principales resultados:

Se han identificado patrones de acumulación específicos de las fases para los ginsenosidos, los fenólicos, los flavonoides y las antocianinas.
Mapa de las vías metabólicas primarias y secundarias junto con la señalización hormonal.
Se descubrieron factores de transcripción clave (MYB, bHLH, ERF) que coordinan los cambios metabólicos.

Conclusiones:

Estableció un marco molecular para el desarrollo de la fruta de Panax ginseng.
Se destacó la regulación transcripcional coordinada y la reprogramación metabólica.
Proporcionó ideas para la ingeniería metabólica para mejorar la producción de compuestos bioactivos.

Palabras clave:

El ginseng Panax Desarrollo de las frutas Integración multiómica Metabolismo primario Metabolismo secundario Factores de transcripción

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