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Asociación entre el índice de triglicéridos y la mortalidad por cualquier causa y cardiovascular en adultos
Chen Yan Yue1,2, Hui Sheng Dong3, Huan Xian Liu4
1Department of Neurology, Qingdao University Affiliated Hospital, Shandong, China.
Medicine
|August 27, 2025
Resumen
El índice de triglicéridos-glucosa (TyG) está relacionado con un aumento de la mortalidad por cualquier causa y cardiovascular en adultos estadounidenses de 40 a 59 años. Los valores más altos del índice TyG predicen un mayor riesgo de muerte, destacando su importancia en la salud cardiovascular.
Área de la Ciencia:
- Cardiología
- Síndrome metabólico
- Epidemiología
Sus antecedentes:
- El índice de triglicéridos-glucosa (TyG) es un marcador emergente para la resistencia a la insulina y la disfunción metabólica.
- Comprender la asociación entre el índice TyG y la mortalidad es crucial para la evaluación del riesgo cardiovascular.
Objetivo del estudio:
- Investigar la asociación entre el índice TyG y la mortalidad por cualquier causa y cardiovascular.
- Evaluar las posibles diferencias relacionadas con la edad en esta asociación.
Principales métodos:
- Análisis de los datos de la Encuesta Nacional de Examen de Salud y Nutrición (1999-2018) que incluyó a 21.959 participantes adultos.
- Se utilizaron modelos de espina cúbica restringida y regresión de Cox para examinar el riesgo de mortalidad.
- Se han realizado análisis de supervivencia por subgrupos y por edades.
Principales resultados:
- El índice elevado de TyG se asoció significativamente con un aumento de la mortalidad por cualquier causa y cardiovascular (P < 0,001).
- Se observó una asociación no lineal, con umbrales identificados para el aumento del riesgo.
- Se observaron diferencias significativas de mortalidad en el grupo de edad de 40 a 59 años.
Conclusiones:
- El índice TyG es un predictor significativo de la mortalidad por todas las causas y cardiovascular en adultos estadounidenses.
- La asociación es particularmente fuerte en el grupo de edad de 40 a 59 años, lo que sugiere una gestión de riesgos específica.
- El índice TyG puede servir como una herramienta valiosa para identificar a las personas con mayor riesgo de resultados cardiovasculares adversos.
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