Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

100
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
100
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

710
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
710
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

86
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
86
Estimating Population Mean with Unknown Standard Deviation01:22

Estimating Population Mean with Unknown Standard Deviation

8.3K
In practice, we rarely know the population standard deviation. In the past, when the sample size was large, this did not present a problem to statisticians. They used the sample standard deviation s as an estimate for σ and proceeded as before to calculate a confidence interval with close enough results. However, statisticians ran into problems when the sample size was small. A small sample size caused inaccuracies in the confidence interval.
William S. Gosset (1876–1937) of the...
8.3K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

126
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
126
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

224
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
224

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Unified estimation for Cox regression model with nonmonotone missing at random covariates.

Statistics in medicine·2022
Same author

Weighted generalized estimating equations and unified estimation for longitudinal data with nonmonotone missing data patterns.

Statistics in medicine·2021
Same author

Statistical inference for missing data mechanisms.

Statistics in medicine·2020
Same journal

Ensuring Quality in Preclinical Research: The Importance of Being Human.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Addressing Cluster-Level Treatment Effect Heterogeneity in Sample Size Determination for Hierarchical 2 × 2 Factorial Designs.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

A Multiple Imputation Approach to Distinguish Curative From Life-Prolonging Effects in the Presence of Missing Covariates.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Tests for Categorical Data Beyond Pearson: A Distance Covariance and Energy Distance Approach.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Nonparametric Estimation of the Patient-Weighted While-Alive Estimand.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Two-Stage Multiple Test Procedures Controlling False Discovery Rate With Auxiliary Variable and Their Application to Set4 <math><semantics><mi>Δ</mi> <annotation>$\Delta$</annotation></semantics></math> Mutant Data.

Biometrical journal. Biometrische Zeitschrift·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Sep 10, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K

Método de estimación unificado para modelos parcialmente lineales con datos no monótonos que faltan al azar

Yang Zhao1

  • 1Department of Mathematics and Statistics, University of Regina, Regina, Saskatchewan, Canada.

Biometrical journal. Biometrische Zeitschrift
|August 27, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio introduce un nuevo método para estimar modelos parcialmente lineales con datos faltantes. El enfoque mejora la eficiencia de la estimación y es robusto, incluso con patrones complejos de datos faltantes.

Palabras clave:
desaparecido al azarPatrones de ausencia no monótonosModelos de trabajo parcialmente linealesmétodo del núcleo lineal local ponderado

Más Videos Relacionados

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.3K

Videos de Experimentos Relacionados

Last Updated: Sep 10, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.3K

Área de la Ciencia:

  • Las estadísticas
  • Estadísticas biológicas
  • Epidemiología

Sus antecedentes:

  • Los modelos parcialmente lineales son cruciales para la inferencia causal en estudios observacionales con variables de confusión.
  • Los métodos existentes luchan con datos faltantes en respuesta, tratamiento y factores de confusión.
  • La robustez y las propiedades libres de distribución asintótica son clave para la prueba de la hipótesis nula causal.

Objetivo del estudio:

  • Desarrollar y evaluar un método de estimación para modelos parcialmente lineales con datos no monótonos que faltan al azar.
  • Mejorar la eficiencia de las estimaciones en comparación con los métodos estándar de casos completos.
  • Proporcionar una solución computacionalmente simple e implementable para escenarios complejos de datos faltantes.

Principales métodos:

  • Desarrolló un método de estimación general utilizando modelos de trabajo parcialmente lineales.
  • Las estimaciones de arranque propuestas para las varianzas asintóticas.
  • Modelos semiparamétricos recomendados para las probabilidades de datos faltantes.

Principales resultados:

  • El estimador propuesto es coherente e independiente de la exactitud del modelo de trabajo.
  • Mejora de la eficiencia de las estimaciones en comparación con los métodos de casos completos.
  • Simplicidad computacional demostrada y implementabilidad en software estándar.

Conclusiones:

  • El nuevo método maneja efectivamente los datos no monótonos que faltan al azar en modelos parcialmente lineales.
  • Ofrece un enfoque robusto y eficiente para la inferencia causal.
  • Validado mediante estudios de simulación y un ejemplo de datos del mundo real.