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Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Las nanopartículas de conversión de ingeniería avanzada para la terapia del cáncer de mama

Shijing Wang1,2, Lei Zhang1, Minghao Wang3

  • 1Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110000, China.

Theranostics
|August 27, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las nanopartículas de conversión ascendente (UCNPs) ofrecen teranosis avanzada para el cáncer de mama (BC) mediante la utilización de luz infrarroja cercana para imágenes y terapia profundas. Estas nanopartículas permiten funciones diagnósticas y terapéuticas integradas para mejorar el manejo de la BC.

Palabras clave:
Detección de biomarcadorescáncer de mamaEntregainmunoterapiaImágenes molecularesfototerapiaLas teranósticasnanopartículas de conversión hacia arriba

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Área de la Ciencia:

  • Nanotecnología
  • Ingeniería biomédica
  • En el campo de la oncología

Sus antecedentes:

  • El cáncer de mama (CC) es un problema de salud mundial que requiere estrategias diagnósticas y terapéuticas innovadoras.
  • Las nanopartículas de upconversion (UCNP) dopadas con tierras raras presentan propiedades fotofísicas únicas para aplicaciones biomédicas.
  • Las UCNPs ofrecen ventajas sobre las sondas convencionales, incluida la penetración en tejidos profundos y la autofluorescencia reducida a través de la absorción de luz de infrarrojo cercano (NIR).

Objetivo del estudio:

  • Proporcionar una revisión exhaustiva de las UCNP diseñadas para el cáncer de mama (BC).
  • Resumir los avances recientes en la síntesis, la funcionalización y la evaluación biológica de la UCNP para la gestión de la BC.
  • Explorar las diversas aplicaciones de UCNPs en imágenes moleculares de BC, detección, terapia e inmunoterapia.

Principales métodos:

  • Revisión de la síntesis de UCNP, incluidos los mecanismos de luminiscencia y los métodos controlables.
  • Análisis de las estrategias de modificación de la superficie de UCNP para una entrega específica y multifuncionalidad.
  • Evaluación sistemática de los efectos biológicos de las UCNP (biodistribución, metabolismo, biotoxicidad) y sus aplicaciones en teranosis.

Principales resultados:

  • Los UCNP diseñados pueden integrar módulos diagnósticos y terapéuticos para la teranosis BC integral.
  • Los UCNP facilitan la obtención de imágenes de tejidos profundos y la terapia dirigida al absorber la luz NIR.
  • Estudios recientes demuestran la eficacia de UCNP en imágenes moleculares de BC, detección de biomarcadores, fototerapia, administración de fármacos / genes y inmunoterapia.

Conclusiones:

  • Los UCNP diseñados representan una plataforma versátil para la teranosis del cáncer de mama avanzado.
  • La investigación adicional sobre los efectos biológicos y la traducción clínica de UCNP es crucial para su adopción generalizada.
  • Los UCNP son prometedores para mejorar el diagnóstico, el tratamiento y los resultados de los pacientes con cáncer de mama.