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Vitamina C en el síndrome de dolor regional complejo en pacientes con fractura del radio distal
Fernando Antonio Silva de Azevedo Filho1,2, Roberta Muniz Blunck1, Abdouni Y Ali3
1Hospital do Subúrbio, Salvador, Bahia, Brazil.
Revista brasileira de ortopedia
|August 27, 2025
Resumen
La suplementación con vitamina C redujo significativamente la incidencia del síndrome de dolor regional complejo (CRPS) y el dolor neuropático en pacientes sometidos a cirugía por fracturas del radio distal. Esta intervención también mejoró el control del dolor postoperatorio.
Área de la Ciencia:
- La ortopedia
- Tratamiento del dolor
- Ciencias de la nutrición
Sus antecedentes:
- El síndrome de dolor regional complejo (CRPS) es una condición debilitante que puede ocurrir después de las fracturas.
- Las fracturas del extremo distal del radio (FDER) son comunes y pueden provocar dolor y discapacidad significativos.
- El papel de las intervenciones nutricionales en la prevención del SCR y el manejo del dolor postoperatorio es un área de investigación en curso.
Objetivo del estudio:
- Investigar la eficacia de la vitamina C en la prevención del SCR después del tratamiento quirúrgico para el extremo distal de las fracturas del radio.
- Evaluar el impacto de la vitamina C en la incidencia y la gravedad del dolor neuropático.
- Evaluar el efecto de la vitamina C en el control general del dolor postoperatorio.
Principales métodos:
- Se realizó un ensayo controlado aleatorizado en el que participaron pacientes adultos con FDER que requirieron cirugía.
- Los participantes fueron asignados a recibir 1g/día de vitamina C o un placebo durante 60 días después de la cirugía.
- Los resultados medidos incluyeron la incidencia de CRPS, el dolor neuropático (usando VAS) y las puntuaciones de dolor en varios momentos.
Principales resultados:
- La incidencia de dolor neuropático fue significativamente menor en el grupo de vitamina C en comparación con el grupo de placebo (p=0,008).
- Los pacientes que recibieron vitamina C informaron puntuaciones de dolor más bajas en la escala analógica visual (VAS) (p=0,001).
- La incidencia del SRC a las 12 y 24 semanas fue estadísticamente más baja en el grupo de intervención con vitamina C (p=0,014 y p=0,007, respectivamente).
Conclusiones:
- La vitamina C demuestra un efecto significativo en la prevención del síndrome de dolor regional complejo (SDRC) después de fracturas del radio distal.
- La suplementación con vitamina C es eficaz para reducir la incidencia del dolor neuropático y mejorar el manejo del dolor postoperatorio.
- Este estudio apoya el uso de vitamina C como terapia adyuvante para pacientes con FDER para mitigar el dolor y prevenir el SRC.
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