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Experiencia clínica a largo plazo con metreleptina en un paciente brasileño con lipodistrofia generalizada congénita
Isabella Sued Leão1, Joana Rodrigues Dantas1, Sarah Galvão2
1Medical Clinic Department, Nutrology and Diabetes Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
JCEM case reports
|August 27, 2025
Resumen
Metreleptina manejó eficazmente la disfunción metabólica en un paciente con lipodistrofia generalizada congénita tipo 2 durante 8 años. El tratamiento continuo con metreleptina es crucial para el control metabólico sostenido en estos pacientes.
Área de la Ciencia:
- Endocrinología
- La genética
- Trastornos del metabolismo
Sus antecedentes:
- La lipodistrofia generalizada congénita tipo 2 (mutación del gen BSCL2) se presenta con resistencia severa a la insulina.
- La metreleptina es una terapia de reemplazo de leptina para la lipodistrofia.
- Existen datos limitados a largo plazo para la metreleptina en la lipodistrofia relacionada con BSCL2.
Palabras clave:
Lipodistrofia generalizada congénitacontrol glucémicoTratamiento de reemplazo de leptinacomplicaciones metabólicasMetreleptina y sus derivadosMás Videos Relacionados
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