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Los gránulos de Zuoqing atenuan la colitis ulcerosa a través de la modulación de la polarización de los macrófagos:
Heng Deng1, Ming Li2, Xiaoli Fang2
1Department of Anorectal Surgery, Second Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, China.
Frontiers in pharmacology
|August 27, 2025
Resumen
Los gránulos de Zuoqing (ZQG) tratan la colitis ulcerosa (UC) mediante la reprogramación de los macrófagos a través de la vía PPAR-γ/ NF-κB/ STAT1. Este estudio aclara las ZQG
Área de la Ciencia:
- Inmunología
- Gastroenterología
- Farmacología
Sus antecedentes:
- Estudios clínicos previos han confirmado la eficacia de los gránulos de Zuoqing (ZQG) para la colitis ulcerosa (UC).
- Los mecanismos inmunomoduladores del ZQG en el tratamiento de la UC no se comprendieron completamente.
- Este estudio investiga los efectos del ZQG en la polarización de los macrófagos y las vías de señalización asociadas.
Objetivo del estudio:
- Elucidar los mecanismos inmunomoduladores de los gránulos de Zuoqing (ZQG) en el tratamiento de la colitis ulcerosa (UC).
- Investigar el impacto de ZQG en la polarización de los macrófagos y las vías de señalización relacionadas.
- Validar el papel de PPAR-γ en los efectos terapéuticos del ZQG.
Principales métodos:
- In vivo: modelo de ratas UC inducido por dextrano sulfato de sodio (DSS) tratado con ZQG.
- In vitro: macrófagos RAW264.7 estimulados por lipopolisacáridos (LPS) tratados con un medio acondicionado con ZQG y un antagonista de PPAR-γ.
- El análisis incluyó histopatología, fenotipo de macrófagos (CD86+/ CD206+), Western blot/ qPCR para las vías de señalización (PPAR-γ, NF-κB, STAT1) y ELISA para las citoquinas.
Principales resultados:
- ZQG redujo el daño y la inflamación del colon dependiendo de la dosis.
- ZQG moduló la polarización de los macrófagos, aumentando el fenotipo M2 y disminuyendo los macrófagos M1.
- ZQG aumentó la regulación de PPAR-γ, suprimió la señalización de NF-κB y STAT1, y reequilibró las citoquinas proinflamatorias y antiinflamatorias.
- Los estudios in vitro confirmaron que el ZQG cambia la polarización de los macrófagos a través de un mecanismo dependiente de PPAR-γ.
Conclusiones:
- Los gránulos de Zuoqing (ZQG) mejoran la colitis ulcerosa (UC) mediante la modulación de la plasticidad de los macrófagos.
- El mecanismo terapéutico involucra el eje de señalización PPAR-γ/ NF-κB/ STAT1.
- Los hallazgos apoyan el ZQG como una terapia multi-objetivo para la UC, con un mecanismo validado dependiente de PPAR-γ.
Palabras clave:
Signalización del PPAR-γ/NF-κB/STAT1Gránulos de ZuoqingPolarización de los macrófagosMedicina tradicional chinaColitis ulcerosa en el hígadoMás Videos Relacionados
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