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Flavonoides prenilados de origen natural de las especies de plantas eritrinas africanas
Bienvenu Tsakem1, Fidele Ntie Kang2,3,4, Rémy Bertrand Teponno5
1Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University Pretoria 0204 South Africa xavier.siwenoundou@smu.ac.za.
RSC advances
|August 27, 2025
Resumen
Las plantas africanas del género *Erythrina* son fuentes ricas de flavonoides prenilados bioactivos. Esta revisión detalla 289 compuestos aislados desde 1981, destacando su distribución y diversas actividades biológicas.
Área de la Ciencia:
- Química de los productos naturales
- Química medicinal
- Fitoquímica
Sus antecedentes:
- Los flavonoides son metabolitos vegetales secundarios con diversas actividades biológicas.
- La prenilación de los flavonoides aumenta su bioactividad.
- El género *Erythrina* es una fuente importante de flavonoides prenilados.
Objetivo del estudio:
- Revisar sistemáticamente los flavonoides prenilados bioactivos de las especies africanas de eritrina.
- Para documentar la distribución de estos compuestos dentro del género.
- Para resumir su aislamiento, elucidación de la estructura y actividades biológicas.
Principales métodos:
- Extensa búsqueda en la literatura de artículos revisados por pares desde 1981 hasta la fecha.
- Se incluyen los estudios que informan sobre el aislamiento y la caracterización de flavonoides prenilados de eritrina africana.
- Compilación de datos sobre la distribución de las especies, las estructuras compuestas, las actividades biológicas y los estudios "in silico".
Principales resultados:
- Se han caracterizado aproximadamente 289 flavonoides prenilados de la eritrina africana.
- Estos compuestos abarcan múltiples subclases de flavonoides, incluidas las flavanonas, las flavonas y las calconas.
- Las actividades biológicas reportadas incluyen propiedades antibacterianas, antioxidantes y anticancerígenas.
Conclusiones:
- Las especies africanas de *Erythrina* representan un recurso valioso para el descubrimiento de nuevos flavonoides prenilados.
- Esta revisión consolida los conocimientos sobre estos compuestos, lo que facilita una mayor investigación en el descubrimiento de fármacos.
- Se requiere una mayor investigación sobre el potencial terapéutico de estos flavonoides prenilados.
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